# US 11,076,762 B2 · Methods and apparatus for express estimation of the arterial elastic property in a subject > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,076,762 B2 - Document ID: US11076762B2 - Status: Granted - Kind: B2 - Application number: 15/919,757 - Filed: 2018-03-13 - Published: 2018-09-20 - Granted: 2021-08-03 - Earliest claimed: 2017-03-13 - Assignees: Rutgers, The State University of New Jersey - Applicants: Rutgers, The State University of New Jersey - Inventors: Evgeny G. Vaschillo; Bronya Vaschillo - Web page: https://patentgrep.com/patent/US11076762B2 ## CPC - A61B 5/02007: {Evaluating blood vessel condition, e.g. elasticity, compliance} - A61B 5/0205: Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition - A61B 5/02108: {from analysis of pulse wave characteristics} - A61B 5/352: Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval - A61B 5/7246: {using correlation, e.g. template matching or determination of similarity} - A61B 5/7257: {using Fourier transforms} - A61B 5/02225: {using the oscillometric method} - A61B 5/02255: {the pressure being controlled by plethysmographic signals, e.g. derived from optical sensors} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract Methods and systems for express estimation of the arterial elasticity in a subject are presented. The methods and systems provide simplicity in measurement and the opportunity to measure the arterial elasticity through HRV. The method includes imposing a rhythmical stimulation at a frequency between about 0.06 Hz and 0.081 Hz to cause an oscillation on the cardiovascular system of a subject. The method further include measuring a response associated with the oscillation on the cardiovascular system and determining the arterial elasticity of the subject based on a level of the response associated with the oscillation. ## Claims ### Claim 1 A method for assessing arterial elasticity, imposing a rhythmical stimulation to cause an oscillation on the cardiovascular system of a subject, wherein the rhythmical stimulation is induced by causing the subject perform a paced sighing at a pacing frequency of about 0.066 Hz or about 0.081 Hz; measuring each of the paced sighing beat-to-beat intervals and pulse transit time (PTT) responses that are associated with the oscillation on the cardiovascular system of the subject caused by the rhythmical stimulation; generating a frequency spectrum for the measured beat-to-beat intervals and PTT responses; and determining an arterial elasticity of the subject by determining heart rate variability (HRV) based on amplitudes of the beat-to-beat intervals and PTT response associated with the oscillation at the pacing frequency in the frequency spectrum. ### Claim 2 (depends on 1) The method of claim 1, wherein the step of imposing the rhythmical stimulation comprises: providing the subject a rhythmical reference cue; and causing the subject to perform the paced sighing in response to the rhythmical reference cue, whereby the paced sighing imposes the rhythmical stimulation on the cardiovascular system of the subject. ### Claim 3 (depends on 2) The method of claim 2, wherein the rhythmical reference cue is a visual cue, an audio cue or a tactile cue. ### Claim 4 (depends on 1) The method of claim 1, wherein the step of measuring the response associated with the oscillation comprises: generating an equidistant waveform based on the beat-to-beat intervals; and generating a frequency domain spectrum from the equidistant waveform by a fast Fourier transform (FFT). ### Claim 5 (depends on 4) The method of claim 4, wherein the step of generating the equidistant waveform comprises: performing cubic interpolation for the beat-to-beat intervals of the subject; and resampling the interpolated beat-to-beat intervals at a rate of 4 Hz. ### Claim 6 (depends on 4) The method of claim 4, wherein the beat-to-beat intervals are measured from a signal from an electrocardiogram (ECG or EKG), plethysmograph, or photoplethysmography (PPG). ### Claim 7 (depends on 4) The method of claim 4, wherein the step of determining the arterial elasticity of the subject comprises determining a power spectrum density of the frequency domain spectrum at a reference frequency. ### Claim 8 (depends on 1) The method of claim 1, wherein the rhythmical stimulation is a sympathetic challenge. ### Claim 9 (depends on 8) The method of claim 8, wherein the sympathetic challenge is a paced sighing sympathetic challenge. ### Claim 10 (depends on 1) A method of evaluating an impact of alcohol consumption on a subject, wherein evaluation of an impact of alcohol consumption is based on a correlation between a drinking profile and the assessment of the arterial elasticity according to claim 1, the drinking profile comprising years of alcohol use of the subject. ### Claim 11 A system for assessing arterial elasticity, comprising: a non-transitory, computer readable memory; one or more processors; and a computer-readable medium containing programming instructions that, when executed by the one or more processors, cause the system to: impose a rhythmical stimulation to cause an oscillation on the cardiovascular system of a subject, wherein the rhythmical stimulation is induced by causing the subject to perform a paced sighing at a pacing frequency of about 0.066 Hz or about 0.081 Hz; measure each of the paced sighing beat-to-beat intervals and PTT responses that are associated with the oscillation on the cardiovascular system of the subject caused by the rhythmical stimulation; generate a frequency spectrum for the measured beat-to-beat intervals and PTT responses; and determine an arterial elasticity of the subject by determining heart rate variability (HRV) based on amplitudes of the beat-to-beat intervals and PTT responses associated with the oscillation at the pacing frequency in the frequency spectrum. ### Claim 12 (depends on 11) The system of claim 11, further comprising programming instructions, when executed by the one or more processors, causing the system to: provide the subject a rhythmical reference cue; and cause the subject to perform the paced sighing to the rhythmical reference cue, whereby the paced sighing imposes the rhythmical stimulation on the cardiovascular system of the subject. ### Claim 13 (depends on 11) The system of claim 11, further comprising programming instructions, when executed by the one or more processors, causing the system to: generate an equidistant waveform based on the beat-to-beat intervals; and generate a frequency domain spectrum from the equidistant waveform by a fast Fourier transform (FFT). ### Claim 14 (depends on 11) The system of claim 11, further comprising programming instructions, when executed by the one or more processors, causing the system to: perform cubic interpolation for the beat-to-beat intervals of the subject; and resample the interpolated beat-to-beat intervals at a rate of 4 Hz. ### Claim 15 (depends on 11) The system of claim 11, further comprising programming instructions, when executed by the one or more processors, causing the system to determine a power spectrum density of the frequency domain spectrum at a reference frequency. ### Claim 16 (depends on 11) The system of claim 11, wherein the rhythmical stimulation is a paced sighing sympathetic challenge.