# US 11,076,757 B2 · System and method for performing objective perimetry and diagnosis of patients with retinitis pigmentosa and other ocular diseases > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 11,076,757 B2 - Document ID: US11076757B2 - Status: Granted - Kind: B2 - Application number: 16/068,994 - Filed: 2017-01-12 - Published: 2019-01-10 - Granted: 2021-08-03 - Earliest claimed: 2016-01-12 - Assignees: Tel Hashomermedical Research Infrastructure and Services, Ltd - Applicants: Tel Hashomer Medical Research Infrastructure and Services, Ltd - Inventors: Ygal Rotenstreich; Ifat Sher - Web page: https://patentgrep.com/patent/US11076757B2 ## CPC - A61B 3/112: {for measuring diameter of pupils} - A61B 3/0008: {provided with illuminating means (A61B3/117, A61B3/14 take precedence)} - A61B 3/0025: {characterised by electronic signal processing, e.g. eye models} - A61B 3/024: for determining the visual field, e.g. perimeter types - A61B 3/11: for measuring interpupillary distance or diameter of pupils - A61B 3/14: Arrangements specially adapted for eye photography - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A system and method for determining a state of health of an eye using a pupillometer is provided comprising an ocular fixture, a testing compartment, a camera, and a controller. The testing compartment comprises a plurality of chromatic beam emitters arranged about a visual field. The ocular fixture is positioned to facilitate exposure of light sensitive ocular structures of the eye to a chromatic stimuli. The camera is positioned to record temporal pupil responses of the eye. The controller controls emission wavelength, intensity, and duration of the chromatic beam emitters. The controller processes temporal pupil response data to generate signals representative of the eye positioned at the ocular fixture in response to the chromatic stimuli at a plurality of locations in the visual field. The method comprises driving the chromatic beam emitters with the controller to generate signals using chromatic stimuli and determining the state of health of the eye. ## Claims ### Claim 1 A method for determining a state of health of an eye using a multifocal pupillometer, wherein: the multifocal pupillometer comprises an ocular fixture, a testing compartment, at least one camera, and a controller; the testing compartment comprises a plurality of chromatic beam emitters arranged about a visual field of the pupillometer, the plurality of chromatic beam emitters are structurally configured to generate chromatic stimuli and to provide red and blue stimuli; the ocular fixture is positioned to facilitate exposure of light sensitive ocular structures of the eye to the chromatic stimuli of the plurality of chromatic beam emitters; the at least one camera is positioned to record temporal pupil contraction of the eye in response to the chromatic stimuli of the plurality of chromatic beam emitters; the controller controls emission wavelength, intensity, and duration of the chromatic beam emitters; the controller processes temporal pupil contraction data recorded by the at least one camera to generate latency of maximal contraction velocity signals and percentage of pupil contraction or maximal contraction velocity signals representative of the eye positioned at the ocular fixture in response to the chromatic stimuli of the plurality of chromatic beam emitters at a plurality of locations in the visual field of the pupillometer; and the method comprises positioning a subject eye at the ocular fixture, driving a selected first subset of the plurality of the chromatic beam emitters with the controller into a first illumination mode to determine an extent of a functional visual field of the subject eye from the percentage of pupil contraction or maximal contraction velocity signals, and driving a selected second subset of the plurality of the chromatic beam emitters with the controller into a second illumination mode to determine the state of health of the subject eye as an objective function of mean absolute deviation in the latency of maximal contraction velocity signals between the plurality of locations in the visual field, wherein the controller selects and drives the second subset of the plurality of chromatic beam emitters based on the extent of the functional visual field determined in the first illumination mode. ### Claim 2 (depends on 1) The method of claim 1, wherein: the selected second subset of the plurality of chromatic beam emitters define an illuminated portion of the visual field of the pupillometer; and the illuminated portion of the visual field of the pupillometer does not extend substantially beyond the functional visual field of the subject eye. ### Claim 3 (depends on 1) The method of claim 1, wherein: the controller selects and drives the selected second subset of the plurality of chromatic beam emitters define an illuminated portion of the visual field of the pupillometer; and the illuminated portion of the visual field of the pupillometer is substantially congruent with the functional visual field of the subject eye. ### Claim 4 (depends on 1) The method of claim 1, wherein the testing compartment comprises: a closed testing compartment comprising a viewing port disposed between/behind the ocular fixture and the plurality of chromatic beam emitters; or an open testing compartment and the chromatic stimuli are generated in a dark room comprising a background luminance of less than about 30 cd/m2. ### Claim 5 (depends on 1) The method of claim 1, wherein the testing compartment is provided in the form of a hemisphere bowl and the plurality of chromatic beam emitters are arranged about the hemisphere bowl. ### Claim 6 (depends on 1) The method of claim 1, wherein one or more of the plurality of chromatic beam emitters are structurally configured to generate the chromatic stimuli within a blue portion of a visible electromagnetic spectrum and one or more of the plurality of chromatic beam emitters are structurally configured to generate the chromatic stimuli within a red portion of the visible electromagnetic spectrum. ### Claim 7 (depends on 1) The method of claim 1, wherein driving the first subset of the plurality of chromatic beam emitters with the controller in the first illumination mode includes using the chromatic stimuli within a blue portion and a red portion of a visible electromagnetic spectrum. ### Claim 8 (depends on 7) The method of claim 7, wherein the chromatic stimuli within the red portion of the visible electromagnetic spectrum have an intensity between about 1 and about up to 1000 times greater than the chromatic stimuli within the blue portion of the visible electromagnetic spectrum. ### Claim 9 (depends on 1) The method of claim 1, wherein driving the second subset of the plurality of chromatic beam emitters with the controller in the second illumination mode includes using the chromatic stimuli within a blue portion and a red portion of a visible electromagnetic spectrum. ### Claim 10 (depends on 9) The method of claim 9, wherein the chromatic stimuli within the red portion of the visible electromagnetic spectrum have an intensity between about 1 and about up to 1000 times greater than the chromatic stimuli within the blue portion of the visible electromagnetic spectrum. ### Claim 11 (depends on 9) The method of claim 9, wherein: the chromatic stimuli within the blue portion of the visible electromagnetic spectrum have a wavelength with a peak value lying in a range from about 450 nm to about 490 nm; and the chromatic stimuli within the red portion of the visible electromagnetic spectrum have a wavelength with a peak value lying in a range from about 620 nm to about 700 nm. ### Claim 12 (depends on 1) The method of claim 1, wherein the controller is configured to activate one or more of the plurality of chromatic beam emitters for a duration between about 0.1 seconds and about 60 seconds. ### Claim 13 A pupillometer comprising: an ocular fixture; a testing compartment; at least one camera; and a controller, wherein the testing compartment comprises a plurality of chromatic beam emitters arranged about a visual field of the pupillometer, one or more of the plurality of chromatic beam emitters are structurally configured to generate chromatic stimuli and configured to provide red and blue stimuli, the ocular fixture is positioned to facilitate exposure of light sensitive ocular structures of an eye to the chromatic stimuli of the plurality of chromatic beam emitters, the at least one camera is positioned to record temporal pupil contraction of the eye in response to the chromatic stimuli of the plurality of chromatic beam emitters, the controller is configured to control emission wavelength, intensity, and duration of the plurality of chromatic beam emitters, the controller is configured to process temporal pupil contraction data recorded by the at least one camera and to generate latency of maximal contraction velocity signals and percentage of pupil contraction or maximal contraction velocity signals representative of the eye positioned at the ocular fixture in response to the chromatic stimuli of the plurality of chromatic beam emitters at a plurality of locations in the visual field of the pupillometer; and the controller is programmed to: drive a first subset of the plurality of chromatic beam emitters into a first illumination mode to determine an extent of a functional visual field of a subject eye from the percentage of pupil contraction or maximal contraction velocity signals, and drive a second subset of the plurality of chromatic beam emitters into a second illumination mode to determine a state of health of the subject eye as an objective function of mean absolute deviation in the latency of maximal contraction velocity signals between the plurality of locations in the visual field, wherein the controller is configured to select and drive a first subset of the plurality of chromatic beam emitters based on the extent of the functional visual field determined in the first illumination mode. ### Claim 14 (depends on 13) The pupillometer of claim 13, wherein the controller is configured to select and drive the second subset of the plurality of chromatic beam emitters to define an illuminated portion of the visual field of the pupillometer, wherein the illuminated portion of the visual field of the pupillometer does not extend substantially beyond the functional visual field of the subject eye. ### Claim 15 (depends on 13) The pupillometer of claim 13, wherein: the controller is configured to select and drive the second subset of the plurality of chromatic beam emitters to define an illuminated portion of the visual field of the pupillometer; and the illuminated portion of the visual field of the pupillometer is substantially congruent with the functional visual field of the subject eye. ### Claim 16 (depends on 13) The pupillometer of claim 13, wherein the testing compartment comprises: a closed testing compartment comprising a viewing port disposed between/behind the ocular fixture and the plurality of chromatic beam emitters; or an open testing compartment and the chromatic stimuli are generated in a dark room comprising a background luminance of less than about 30 cd/m2. ### Claim 17 (depends on 13) The pupillometer of claim 13, wherein the testing compartment is provided in the form of a hemisphere bowl and the plurality of chromatic beam emitters are arranged about the hemisphere bowl. ### Claim 18 (depends on 13) The pupillometer of claim 13, wherein the second subset of plurality of chromatic beam emitters with the controller in the second illumination mode includes using the chromatic stimuli within a blue portion and a red portion of a visible electromagnetic spectrum. ### Claim 19 (depends on 18) The pupillometer of claim 18, wherein the chromatic stimuli within the red portion of the visible electromagnetic spectrum have an intensity between about 1 and about up to 1000 times greater than the chromatic stimuli within the blue portion of the visible electromagnetic spectrum. ### Claim 20 (depends on 18) The pupillometer of claim 18, wherein: the chromatic stimuli within the blue portion of the visible electromagnetic spectrum have a wavelength with a peak value lying in a range from about 450 nm to about 490 nm; and the chromatic stimuli within the red portion of the visible electromagnetic spectrum have a wavelength with a peak value lying in a range from about 620 nm to about 700 nm.