# US 11,076,599 B2 · Antimicrobial coating comprising chalcogenide nano-particles capped by chitosan

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- Number: US 11,076,599 B2
- Document ID: US11076599B2
- Status: Granted
- Kind: B2
- Application number: 16/499,137
- Filed: 2018-03-28
- Published: 2020-08-13
- Granted: 2021-08-03
- Earliest claimed: 2017-03-28
- Assignees: Board of Regents, The University of Texas System
- Applicants: Kelly L. Nash; Grégory Guisbiers; Humberto Herman Lara Villegas
- Inventors: Kelly L. Nash; Grégory Guisbiers; Humberto Herman Lara Villegas
- Web page: https://patentgrep.com/patent/US11076599B2

## CPC

- A01N 59/02: Sulfur; Selenium; Tellurium; Compounds thereof
- A61K 31/722: Chitin, chitosan
- A01N 25/10: Macromolecular compounds
- A61K 33/04: Sulfur, selenium or tellurium; Compounds thereof
- Y02A 50/30: Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

## Abstract

Disclosed herein are methods of making pure chalcogenide (e.g., selenium, tellurium, or selenium/tellurium) nanoparticles by irradiating chalcogenide pellets by nano-second laser ablation using chitosan as a capping agent to form chitosan chalcogenide nanoparticles (CS-CgNPs). CS-CgNPs and methods of using such particles are also disclosed herein, such as antimicrobials and antimicrobial coatings effective against biofilms.

## Claims

### Claim 1

A method for producing an antimicrobial coating on a surface, the method comprising: mixing a chitosan capped chalcogenide nanoparticle with an application material to form a mixture; applying the mixture on the surface forming a surface having a chitosan capped chalcogenide nanoparticles on or in the surface that inhibit biofilm formation of bacteria and fungus, wherein the chitosan capped chalcogenide nanoparticle is present in the mixture in an amount from about 0.0001 wt. % to about 10 wt. %.

### Claim 2 (depends on 1)

The method of claim 1, wherein the chalcogenide nanoparticle is a selenium nanoparticle.

### Claim 3 (depends on 1)

The method of claim 1, wherein the biofilm comprises bacteria, fungi, or combinations thereof.

### Claim 4 (depends on 1)

The method of claim 1, wherein the biofilm comprises Streptococcus, Staphylococcus aureus, MRSA, Candida albicans, Pseudomonas aeruginosa, E. coli or combinations of bacterial with fungal biofilms thereof.

### Claim 5 (depends on 1)

The method of claim 1, wherein the chitosan capped chalcogenide nanoparticles are present on the surface at a density of 0.01 to 1.0 mg/m2.

### Claim 6 (depends on 1)

The method of claim 1, wherein the chitosan capped chalcogenide nanoparticles are present on the surface at a density of about 0.15 mg/m2.

### Claim 7 (depends on 1)

The method of claim 1, wherein the chitosan capped chalcogenide nanoparticles have an average diameter greater than or equal to about 20 nanometers and less than or equal to about 100 nanometers.

### Claim 8 (depends on 1)

The method of claim 1, wherein the surface is a bandage surface, a catheter surface, a textile surface, a pipe surface, a tube surface, a cooking surface, medical device surface or a bed surface.