# US 11,076,543 B2 · Compositions and their use for pest control and to induce plant hormone and gene regulation for improved plant production and defense

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- Number: US 11,076,543 B2
- Document ID: US11076543B2
- Status: Granted
- Kind: B2
- Application number: 16/707,136
- Filed: 2019-12-09
- Published: 2020-04-23
- Granted: 2021-08-03
- Earliest claimed: 2015-08-10
- Assignees: Biodel Inc.
- Applicants: Biodel AG Inc.
- Inventors: Lance William Beem; Stephen Michael Butler; George Benjamin Cloud
- Web page: https://patentgrep.com/patent/US11076543B2

## CPC

- A01H 3/04: by treatment with chemicals
- A01N 65/12: Asteraceae or Compositae [Aster or Sunflower family], e.g. daisy, pyrethrum, artichoke, lettuce, sunflower, wormwood or tarragon
- A01H: NEW PLANTS OR {NON-TRANSGENIC} PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS

## Abstract

The subject invention provides compositions and methods of using the same for improving plants' defense by employing naturally-derived chemicals. In a specific embodiment, the composition is from Parthenium argentatum Gray, also known as the guayule plant. Preferred compositions can up-or down-regulate growth genes responsible for the targeted plants' defense mechanisms in order to create physical and/or chemical barriers, and produce detouring exudates, antagonistic compounds, or fumigating compounds that prevent and treat damages from pests in agronomic or non-agronomic plants.

## Claims

### Claim 1

A method of protecting a plant against plant pest, wherein said method comprises applying, to the plant, and/or to the plant pest, a composition comprising a bioactive aqueous extract from the roots of a Parthenium argentatum Gary plant wherein said roots have been separated from the rest of the plant, milled to a size of ¼ inch or less, and extracted by placing them in an aqueous solvent; and wherein the milled roots have been removed from the aqueous solvent thereby obtaining the bioactive aqueous extract, and wherein the composition comprises at least 15 compounds selected from ornithine; butane-2,3-diol; alanine; erythritol; mannitol; lyxitol; valine; quinic acid; 3-hydroxypropionic acid; phenylethylamine; succinic acid; 6-deoxyglucose; glycine; myo-inositol; lactic acid; glutamic acid; aspartic acid; putrescine; isoleucine; propane-1,3-diol; tyrosine; oxoproline; histidine; phosphate; 3,4-dihydroxycinnamic acid; N-methylalanine; uridine; ribonic acid; glycerol and urea.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the plant pest is selected from insects and nematodes.

### Claim 3 (depends on 2)

The method, according to claim 2, wherein the plant pest is a nematode.

### Claim 4 (depends on 1)

The method, according to claim 1, wherein the plant is selected from row crops, field crops, tree crops, citrus crops, fruit crops, turf crops, ornamental crops, vegetables and vine crops.

### Claim 5 (depends on 1)

The method, according to claim 1, wherein the composition comprises butane-2,3-diol; erythritol; valine; quinic acid; 3-hydroxypropionic acid; glycine; lactic acid; glutamic acid; aspartic acid and 3,4-dihydroxycinnamic acid.