Poly(ADP-ribose) polymerase inhibitor, preparation method and use
AssigneeSelection Bioscience LLC
InventorsFuyao Zhang, Hongshun Yuan, Xiaoming Shen
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Abstract
Disclosed are a compound as shown in general formula I, a pharmaceutically acceptable salt, an isomer or a mixture thereof, and a solvate, a polymorph, a stable isotope derivative or a prodrug thereof. The compound of the present disclosure has comparatively strong PARP inhibitory activity and can be used for treating diseases associated with PARP, such as cancers and inflammatory diseases.
Claims20
A compound as shown in general formula I, a pharmaceutically acceptable salt thereof, an isomer thereof or a mixture form of the isomers, a solvate thereof, a polymorph thereof, a stable isotope derivative thereof or a prodrug thereof;
- wherein,
- Ra is selected from fluorine, substituted or unsubstituted C1-6 alkyl or substituted or unsubstituted cycloalkyl;
- Rb is selected from hydrogen, deuterium, substituted or unsubstituted C1-6 alkyl or substituted or unsubstituted cycloalkyl;
- R1, R2, R3, R4, R5, R6, R7, R8 and R9 are each independently selected from hydrogen, deuterium or fluorine
- m is the number of R7 and is 0, 1, 2, 3, or 4;
- and
- n is the number of R9 and is 0, 1, 2, or 3.
Dependencies are inferred from the claim text.