Butyrylcholinesterase zwitterionic polymer conjugates
AssigneeKodiak Sciences Inc.
InventorsDaniel Victor Perlroth, Stephen A. Charles, Wayne To, Xiaojian Huang, Martin Linsell, Didier Benoit
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Abstract
The present invention provides recombinant butyrylcholinesterase fusion proteins, including Fc fusion proteins and multi-armed high MW polymers containing hydrophilic groups conjugated to the fusion proteins, and methods of preparing such polymers.
Claims26
A conjugate comprising a butyrylcholinesterase covalently bound to a zwitterionic polymer wherein the polymer comprises one or more types of monomer units and wherein at least one type of monomer unit comprises a zwitterionic group, wherein the butyrylcholinesterase is fused to an immunoglobulin (Ig) domain as fusion protein.
A butyrylcholinesterase enzyme fusion protein comprising:
- a butyrylcholinesterase enzyme;
- a linker connected to the butyrylcholinesterase enzyme;
- an immunoglobulin (Ig) domain connected to the linker,
- wherein the butyrylcholinesterase enzyme has a mutation, wherein the residue C94 of SEQ ID NO:
- 1 is Y.
Dependencies are inferred from the claim text.