Method of treatment using nanoparticulate ganaxolone formulations

A method of treatment for depression, comprising administering to a human patient in need thereof a therapeutically effective amount of an oral dosage form comprising stabilized ganaxolone particles comprising ganaxolone, a hydrophilic polymer in an amount from about 3% to about 50%, w/w, a wetting agent in an amount from about 0.05% to about 2%, w/w, based on the weight of the composition, and a complexing agent selected from the group of small organic molecules having a molecular weight less than 550 and containing a moiety selected from the group consisting of a phenol moiety, an aromatic ester moiety and an aromatic acid moiety, the complexing agent being included in an amount from about 0.05% to about 5%, w/w, based on the weight of the solid particles, wherein the stabilized particles have a volume weighted median diameter (D50) of the particles from about 50 nm to about 500 nm and the concentration of ganaxolone in the solid stabilized particles is at least 50% by weight, wherein the therapeutically effective amount of ganaxolone is sufficient to provide treatment to the human patient suffering from depression.