Recombinant Corynebacterium capable of producing biliverdin IX-alpha and method of producing biliverdin IX-alpha using the same
AssigneeKorea University Research and Business Foundation
InventorsSung Ok Han, Jiho Seok, Young-jin Ko
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Abstract
Disclosed are recombinant strain of a genus Corynebacterium capable of producing biliverdin IX-alpha (IXα) and a method of producing biliverdin IX-alpha using the same. The recombinant strain is capable of synthesizing biliverdin IX-alpha in an environmentally friendly manner using only glucose without the addition of any nitrogen source, thus replacing the synthesis of biliverdin IX-alpha through chemical treatment, which is a conventional synthetic method causing environmental pollution problems.
Claims4
A recombinant strain of a genus Corynebacterium having capability to produce biliverdin IX-alpha, wherein a hemA gene comprising the nucleotide sequence of SEQ ID NO:1 and a hemL gene comprising the nucleotide sequence of SEQ ID NO:2 are amplified, and wherein a hemQ gene comprising the nucleotide sequence of SEQ ID NO:3 or a hmuO gene comprising the nucleotide sequence of SEQ ID NO:4 is introduced by a recombinant vector in a form of hemQ or hmuO.
A recombinant strain of a genus Corynebacterium having capability to produce biliverdin IX-alpha, wherein a hemA gene comprising the nucleotide sequence of SEQ ID NO:1, a hemL gene comprising the nucleotide sequence of SEQ ID NO:2, a hemQ gene comprising the nucleotide sequence of SEQ ID NO:3, and hmuO gene comprising the nucleotide sequence of SEQ ID NO:4, are amplified, and wherein the hemQ gene and the hmuO gene are introduced by a recombinant vector in a form of hemQO, in which the hemQ gene is located in front of the hmuO gene in the recombinant vector.
Dependencies are inferred from the claim text.