Zika as a cell penetrating peptide for delivery to the brain
AssigneeBuck Institute for Research on Aging
InventorsBarbara J. Bailus, Lisa M. Ellerby
Life of this patent
Estimating the term…
Abstract
In various embodiments constructs are provided for the delivery of an effector molecule into a cell. In certain embodiments the construct comprises a cell penetrating peptide (CPP) attached to an effector that is to be delivered into a cell, where the cell penetrating peptide comprises a Zika cell penetrating peptide (Zika CPP), and the effector is selected from the group consisting of a protein, a nucleic acid, an organic compound, a nanoparticle, a viral particle, and the like.
Claims25
A construct comprising a cell penetrating peptide attached to an effector that is to be delivered into a cell, wherein:
- said cell penetrating peptide comprises a Zika cell penetrating peptide (Zika CPP) where the amino acid sequence of said cell penetrating peptide comprises the sequence ENLEYRIMLSVHGSQHSGMIVNDTG HETDENRAKVEITPNSPR (SEQ ID NO:1), or a fragment thereof that retains the ability to penetrate into a target cell, and said cell penetrating peptide ranges in length up to 50 amino acids;
- and
- said effector is selected from the group consisting of a protein that is not a Zika protein, a nucleic acid, an organic compound, a viral particle, and a nanoparticle.
Dependencies are inferred from the claim text.