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US 11,066,390 B2Granted
Solid state forms of Ivosidenib
AssigneeAssia Chemical Industries Ltd.
InventorsAnantha Rajmohan Muthusamy, Amit Singh, Venkata Subbarao Yazali, Parven Kumar Luthra, Sanjay Lakhabhai Vasoya, Bhatu Tumba Patil, Amit Kumar Taneja, Naveen Chandra Srivastav, Rinku Singh, Vadivelan Rengasamy, Abhilash Tyagi
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Abstract
Solid state forms of Ivosidenib, processes for preparation thereof, pharmaceutical compositions thereof, and uses thereof are disclosed.
Claims5
Crystalline Form T11 of Ivosidenib, which is characterized by data selected from one or more of the following:
- i. an XRPD pattern having peaks at 14.3, 15.9, 21.2, 22.7 and 23.8 deg-2-theta±0.2 deg 2-theta;
- ii. an XRPD pattern as depicted in FIG. 12;
- iii. a solid state 13C—NMR spectrum with peaks at 178.4, 172.3, 151.8, 147.7 and 131.3 ppm±0.2 ppm;
- iv. a solid state 13C—NMR spectrum having the following chemical shift absolute differences from a peak at 57.8 ppm±2 ppm of 120.6, 114.5, 94.0, 89.9 and 73.5 ppm±0.1 ppm;
- v. a solid state 13C NMR spectrum having chemical shift difference from a peak at 178.4 ppm±1 ppm of 120.6 ppm±0.1 ppm;
- vi. a solid state 13C—NMR spectrum substantially as depicted in FIG. 27;
- or combinations of (i)-(vi).
4 more elements
Dependencies are inferred from the claim text.