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US 11,066,352 B2Granted
Processes of making L-ornithine phenylacetate
AssigneeOcera Therapeutics, Inc.
InventorsLudwig Pilsl, Georg Winkler, Frank Demartin, Vassil Elitzin
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Abstract
Embodiments of the present disclosure are related to improved processes for making L-ornithine phenylacetate without using any silver salts or forming any L-ornithine intermediate salts, such as a benzoate salt. The present processes may be used in the commercial scale manufacturing of L-ornithine phenylacetate with high yields and low impurities.
Claims18
A process of making L-ornithine phenylacetate, comprising:
- intermixing L-ornithine hydrochloride and potassium hydroxide in a first solvent to form a first reaction mixture, wherein the first solvent comprises water;
- adding a second solvent to said first reaction mixture, wherein the second solvent comprises ethanol;
- isolating potassium chloride from said first reaction mixture;
- intermixing phenylacetic acid with said first reaction mixture to form a second reaction mixture;
- and
- isolating a composition comprising L-ornithine phenylacetate from said second reaction mixture.
3 more elements
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