US 11,065,328 B2 · Vaccine against infectious bronchitis virus

Abstract

Embodiments of the present invention relate to an infectious bronchitis virus (IBV) and an immunogenic composition comprising an IBV, respectively, wherein the ORF 3a and/or the ORF 3b and/or the ORF 5a and/or the ORF 5b is inactivated. Furthermore, aspects of the present invention relate to methods for immunizing a subject comprising administering to such subject the immunogenic composition of the present invention. Moreover, embodiments of the present invention relate to methods of treating or preventing clinical signs caused by IBV in a subject of need, the method comprising administering to the subject a therapeutically effective amount of an immunogenic composition according to the embodiments of the present invention.

Claims15

Dependent claims

A safe and efficacious vaccine against infectious bronchitis virus (IBV), comprising:

an IBV in an amount effective to reduce the incidence or severity of tracheal lesions in an animal immunized with the IBV, relative to a non-immunized control animal of the same species, when subsequently infected with a pathogenic IBV strain;
and
a pharmaceutically acceptable carrier,
wherein the IBV comprises an inactivated ORF 5a that attentuates a virulent parent strain.

1 more element

Dependencies are inferred from the claim text.

Vaccine against infectious bronchitis virus

Life of this patent

Vaccine against infectious bronchitis virus

Life of this patent

Abstract

Claims15