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US 11,065,202 B2Granted
Multi-component nanochains
AssigneeCase Western Reserve University
InventorsEfstathios Karathanasis, Watuthantrige Pubudu M Peiris, Mark Griswold
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Abstract
A multi-component nanochain for use in diagnostic and therapeutic applications includes at least three nanoparticles linked together to form the nanochain. At least one nanoparticle of the nanochain has an asymmetric surface chemistry defined by asymmetrically disposed first linkers and second linkers. The nanoparticles are linked to form the nanochain by linking first linkers and/or second linkers disposed on separate nanoparticles.
Claims18
A method of treating cancer in a subject, the method comprising:
- administering to the subject a multi-component nanochain that includes at least three nanoparticles linked together to form the nanochain, at least one nanoparticle of the nanochain having asymmetric surface chemistry defined by asymmetrically disposed first linkers and second linkers, the nanoparticles being linked to form the nanochain by linking first linkers and/or second linkers disposed on separate nanoparticles, at least one nanoparticle comprising or being linked to an anti-cancer agent.
Dependencies are inferred from the claim text.