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US 11,060,078 B2Granted
Engineered CRISPR-Cas9 nucleases
AssigneeThe General Hospital Corporation
InventorsJ. Keith Joung, Benjamin Kleinstiver, Vikram Pattanayak
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Abstract
Engineered CRISPR-Cas9 nucleases with improved specificity and their use in genomic engineering, epigenomic engineering, genome targeting, and genome editing.
Claims29
A Staphylococcus aureus Cas9 (SaCas9):single guide RNA (sgRNA) complex comprising a SaCas9 protein that is at least 95% identical to SEQ ID NO:
- 2, with mutations at one, two, three, four, five, six, or more of the following positions:
- Y211, Y212, W229, Y230, R245, T392, N419, Y651, or R654.
Dependencies are inferred from the claim text.