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US 11,060,074 B2Granted
Self-regenerating hyaluronan polymer brushes
AssigneeGeorgia Tech Research Corporation
InventorsJennifer E. Curtis, M. G. Finn, Wenbin Wei, Jessica Faubel
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Abstract
The present invention provides polymer brush constructs, for example, surfaces decorated with hyaluronan polymers, and methods of making the same. The constructs are useful as functional materials for numerous applications, e.g., as lubricants, implant coatings, bandages and other uses.
Claims19
A polymer brush comprising:
- a substrate;
- and
- hyaluronan synthase components attached to about 20 to about 40% of the surface area of the substrate, at least a portion of which being capable of synthesizing a hyaluronic acid having a certain hydrodynamic diameter;
- wherein one or more of the hyaluronan synthase components comprise one or more hyaluronan synthase proteins in a fragment of cell membrane;
- and
- wherein an average distance between the hyaluronan synthase proteins in the fragment of cell membrane is substantially equal to or less than an average hydrodynamic diameter of the hyaluronic acid.
3 more elements
A polymer brush comprising:
- a substrate;
- and
- hyaluronan synthase components attached to the substrate, at least a portion of which being capable of synthesizing a hyaluronic acid having a certain hydrodynamic diameter;
- wherein one or more of the hyaluronan synthase components comprise one or more hyaluronan synthase proteins in a fragment of cell membrane;
- wherein an average distance between the hyaluronan synthase proteins in the fragment of cell membrane is substantially equal to or less than an average hydrodynamic diameter of the hyaluronic acid;
- and
- wherein one or more of:
- the hyaluronan synthase components comprise about 20 to about 40% of the surface area of the substrate;
- an average distance between the hyaluronan synthase components on the substrate is less than about 1 μm;
- the hyaluronic acid is an azide-modified hyaluronic acid;
- an average height of the polymer brush is in the range of about 500 nm to about 30 μm;
- an average size of the hyaluronan is less than about 12 MDa;
- and
- a grafting density of the polymer brush is modified such that it comprises regions comprising inactivated hyaluronan synthase components that are not capable of synthesizing polysaccharide.
11 more elements
Dependencies are inferred from the claim text.