Anti-IFNAR1 antibodies for treating autoimmune diseases
AssigneeI-Mab Biopharma US Limited
InventorsWei Cao, Weili Xu
Life of this patent
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Abstract
Provided are antibodies or fragments thereof having binding specificity to the human interferon alpha and beta receptor subunit 1 (IFNAR1) protein. In various examples, the antibodies or fragments thereof include a VH and VL CDRs as provided, or variants thereof. Methods of using the antibodies or fragments thereof for treating autoimmune diseases and disorders are also provided.
Claims15
An antibody or fragment thereof having specificity to a human interferon alpha and beta receptor subunit 1 (IFNAR1) protein, wherein the antibody or fragment thereof comprises a heavy chain variable region comprising heavy chain complementarity determining regions HCDR1, HCDR2, and HCDR3, and a light chain variable region comprising light chain complementarity determining regions LCDR1, LCDR2, and LCDR3, wherein the HCDR1, HCDR2, HCDR3, LCDR1, LCDR2, and LCDR3 are
- HCDR1:
- DYYMH (SEQ ID NO:
- 77), HCDR2:
- RIDPEDGETKYAPKFQG (SEQ ID NO:
- 78) or RIDPEDAETKYAPKFQG (SEQ ID NO:79), HCDR3:
- GGNFYVMDY (SEQ ID NO:
- 80), LCDR1:
- KASQNVGTNVV (SEQ ID NO:
- 81), LCDR2:
- SASYRVS (SEQ ID NO:
- 82), and LCDR3:
- QQKNNYPYT (SEQ ID NO:
- 83).
Dependencies are inferred from the claim text.