Catalytically active protein aggregates and methods for producing the same

A water-insoluble protein aggregate comprising a fusion protein, wherein said fusion protein comprises a coiled-coil domain and a catalytic domain, said water-insoluble protein aggregate possesses catalytic activity and the fusion protein is aggregated in an inclusion body, wherein the coiled-coil domain is encoded by a nucleotide sequence selected from the group consisting of SEQ ID NO:

• 2 and SEQ ID NO:
• 4, or nucleotide sequences having at least 80% sequence identity to said nucleotide sequences, and wherein said nucleotide sequence of SEQ ID NO:
• 2 or SEQ ID NO:
• 4 encodes the amino acid sequence of SEQ ID NO:1 or SEQ ID NO:3, respectively.