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US 11,059,864 B2Granted
Chimeric antigen receptor (CAR) modulation
AssigneeTrustees of Boston University
InventorsJohn Ngo, Wilson Wong, Meng Lai Nicole Wong, Huishan Li, Elliot P. Tague
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Abstract
The technology described herein is directed to CAR polypeptides and systems comprising repressible proteases. In combination with a specific protease inhibitor, the activity of said CAR polypeptides and systems and cells comprising them can be modulated. Also described herein are methods of using said CAR polypeptides and systems, for example to treat various diseases and disorders.
Claims23
A polypeptide comprising, from N-terminus to C-terminus:
- a) an extracellular binding domain comprising an antigen-binding fragment of an antibody;
- b) a transmembrane domain;
- c) a first intracellular signaling domain comprising an intracellular domain of a costimulatory molecule;
- d) a repressible protease;
- and
- e) the combination of A) an immunoreceptor tyrosine-based activation motif (ITAM) containing primary cytoplasmic signaling sequence, and B) a second intracellular signaling domain comprising an intracellular domain of a costimulatory molecule;
- wherein the ITAM containing primary cytoplasmic signaling sequence and the second intracellular signaling domain comprising an intracellular domain of a costimulatory molecule can be in any N-terminus to C-terminus order relative to each other.
4 more elements
Dependencies are inferred from the claim text.