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US 11,059,782 B2Granted
Method for aromatic fluorination
AssigneesDow Global Technologies LLC, The Regents of the University of Michigan
InventorsMelanie S. Sanford, Megan A. Cismesia, Patrick S. Hanley, Douglas Bland
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Abstract
Disclosed is a fluorination method comprising providing a fluorinating reagent and a solvent to a reaction mixture; providing a compound having the formula Ar—X to the reaction mixture; wherein Ar is aryl, substituted aryl, heteroaryl or substituted heteroaryl, and X is Cl, Br, I or NO2, providing tetramethylammonium 2,6-dimethylphenolate to the reaction mixture; and reacting under conditions sufficient to provide a species having the formula Ar—F.
Claims17
A fluorination method comprising:
- providing a solvent to a reaction mixture;
- providing a fluorinating reagent to the reaction mixture;
- providing a compound having the formula Ar—X to the reaction mixture;
- wherein:
- Ar is aryl, substituted aryl, heteroaryl or substituted heteroaryl, and
- X is Cl, Br, I or NO2;
- providing a tetraalkyl ammonium phenolate salt to the reaction mixture;
- and
- reacting under conditions sufficient to provide a species having the formula Ar—F.
6 more elements
Dependencies are inferred from the claim text.