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AssigneesZoetis Services LLC, Iowa State University Research Foundation, Inc.
InventorsJianqiang Zhang, Qi Chen, Phillip Gauger, Darin Madson, John Morgan Hardham, Meggan Bandrick, Jay Gregory Calvert, James Richard Thompson, Mira Ivanova Stoeva, Walter Valdez
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The present invention is directed to novel nucleotide and amino acid sequences of Porcine Epidemic Diarrhea Virus (“PEDV”), including novel genotypes thereof, all of which are useful in the preparation of vaccines for treating and preventing diseases in swine and other animals. Vaccines provided according to the practice of the invention are effective against multiple swine PEDV genotypes and isolates. Diagnostic and therapeutic polyclonal and monoclonal antibodies are also a feature of the present invention, as are infectious clones useful in the propagation of the virus and in the preparation of vaccines. Particularly important aspects of the invention include polynucleotide constructs that replicate in tissue culture and in host swine. The invention also provides for novel full length PEDV genomes that can replicate efficiently in host animals and tissue culture.
An isolated Porcine Epidemic Diarrhea Virus (PEDV) encoded by a DNA polynucleotide sequence that is SEQ ID NO:
An isolated Porcine Epidemic Diarrhea Virus (PEDV) that is encoded by a DNA polynucleotide sequence that is at least 95% or 99% identical, at a full length nucleotide level, to SEQ ID:
Dependencies are inferred from the claim text.