N-antigenic form poliovirus virus-like particles comprising thermostable mutations
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsJames B. Flanegan, Robert McKenna, Christopher Daniel Boone, Sushma Abraham Ogram, Barbara Joan Morasco
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Abstract
Provided herein are compositions of virus like particles (VLPs) of poliovirus (PV) that have one or more stabilizing mutations that confer a higher degree of thermostability to the N-antigenic form of the VLPs. These VLPs are non-infectious, and thus safer for use in vaccine development and administration to clinical subjects.
Claims18
A composition comprising poliovirus (PV) virus like particles (VLPs) comprising one or more stabilizing mutations, wherein the VLPs are thermostable in N-antigenic form, and wherein the one or more stabilizing mutations comprise:
- VP3(178Q.L) in SEQ ID NO:
- 4, VP3(167V.D) in SEQ ID NO:
- 4, VP3(4V.C) in SEQ ID NO:
- 4, VP1(147N.C) in SEQ ID NO:
- 5, VP1(231A.V) in SEQ ID NO:
- 5, and/or VP2(201R.K) in SEQ ID NO:
- 3.
A composition comprising poliovirus (PV) virus like particles (VLPs) comprising one or more stabilizing mutations, wherein the VLPs are thermostable in N-antigenic form, and wherein the one or more stabilizing mutations comprise VP3(178Q.L) in SEQ ID NO:
- 4.
A composition comprising poliovirus (PV) virus like particles (VLPs) comprising a stabilizing mutation, wherein the VLPs are thermostable in N-antigenic form, and wherein the stabilizing mutation consists of VP3(178Q.L) in SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.