Methods and compositions for treating mucosal tissue disorders
AssigneeThe University of North Carolina at Chapel Hill
InventorsRoland R. Arnold, David C. Henke
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Abstract
The present invention provides compositions and formulations comprising glutathione with or without thiocyanate and methods of use thereof to treat diseases and disorders in mucosal/epithelial tissue.
Claims24
A method of treating, inhibiting, or reducing the severity of an infection by Mycobacterium other than tuberculosis (MOTT) in the airway of a subject in need thereof, comprising administering to the airway of the subject by inhalation an effect amount of a composition consisting essentially of:
- a) a glutathione or a pharmaceutically acceptable salt of glutathione;
- b) an organic acid or a pharmaceutically acceptable salt of an organic acid;
- and
- c) a carrier, wherein the composition has a pH from about 5 to about 9.
A method of restoring homeostasis to and/or maintaining homeostasis in an airway mucosal membrane to treat, inhibit or reduce the severity of Mycobacterium other than tuberculosis (MOTT) infection in the airway of a subject in need thereof, comprising administering to the airway of the subject by inhalation an effective amount of a composition consisting essentially of:
- a) a glutathione, or a pharmaceutically-acceptable salt of glutathione;
- b) an organic acid, or a pharmaceutically-acceptable salt of an organic acid;
- and
- c) a carrier, wherein the composition has a pH from about 5 to about 9, and wherein the subject is an immunocompromised subject, a transplant recipient, and/or a subject at increased risk of an opportunistic infection.
A method of reducing the growth of Mycobacterium other than tuberculosis (MOTT) in the airway of a subject in need thereof, comprising administering to the airway of the subject by inhalation an effective amount of a composition consisting essentially of:
- a) a glutathione, or a pharmaceutically-acceptable salt of glutathione;
- b) an ascorbic acid, or a pharmaceutically-acceptable salt of an ascorbic acid;
- and
- c) a carrier, wherein the composition has a pH from about 5 to about 9.
Dependencies are inferred from the claim text.