Controller-based apparatus and method for diagnosis and treatment of acquired brain injury and dysfunction

A non-transitory storage medium, encoded with instructions for a diagnostic and treatment program, which when executed on a system having a controller, a display, a stimulus array, and a sensor array, establishes processes for performing a protocol for the diagnosis and the treatment of a subject with acquired brain injury, by stimulation of afferent fibers so as indirectly to cause improvement in the area of the brain affected by the injury, and in overall brain function, the program operating under guidance of a health practitioner;

• wherein:
• the display is coupled to the controller and configured by the program to provide data to the health practitioner concerning performance of the subject under the protocol as well as a user interface for the health practitioner to operate the diagnostic and treatment program;
• the stimulus array is coupled to the controller and configured to provide stimulation to the subject, the stimulation being provided from a stimulus set selected from the group consisting of TENS, non-painful heat, non-painful cold, visual, occulo-motor stimulation, crude touch, olfactory stimulation, vestibular stimulation, auditory stimulation and combinations thereof;
• and
• the sensor array is coupled to the controller and configured to monitor a response set of autonomic physiological responses of the subject, to such stimulation, the response set selected from the group consisting of oxygen saturation, heart rate, pupillary response, blood pressure, sweat production, sudomotor activity, and respiration;
• (a) wherein the protocol includes diagnostic processes comprising:
• providing by the controller, under control of the program, directions to the subject to assume sequentially a plurality of distinct postures in a posture set selected from the group consisting of walking, standing, sitting, prone and supine;
• while the subject is in each of the selected postures,
• using the stimulus array, under control of the program, to provide to the subject sequentially each stimulus in the stimulus set so as to provide diagnostic stimulation, while using the sensor array, under control of the program, to monitor the set of autonomic physiological responses of the subject to the diagnostic stimulation;
• storing, under control of the program, diagnostic response data characterizing the responses of the subject to such diagnostic stimulation;
• retrieving, under control of the program, the diagnostic response data;
• processing, under control of the program, the diagnostic response data to identify the posture, hereinafter the “primary posture,” wherein the physiological responses of the subject exhibit a least amount of dysfunction relative to their corresponding statistical norms;
• processing, under control of the program, the diagnostic response data identifying the stimulus, hereinafter the “primary stimulus,” with respect to which the physiological responses of the subject exhibit a change in the amount of dysfunction towards their corresponding statistical norms when the subject is in the primary posture;
• and
• (b) wherein the protocol includes treatment processes comprising:
• (i) providing by the controller, under control of the program, direction to the subject to assume the primary posture;
• (ii) while the subject is in the primary posture, using the stimulus array, under control of the program, to provide treatment stimulation to the subject by the primary stimulus in the stimulus set while using the sensor array, under control of the program, to monitor the set of autonomic physiological responses of the subject to the treatment stimulation;
• (iii) storing, under control of the program, treatment response data characterizing the responses of the subject to the treatment stimulation;
• and
• (iv) under control of the program, retrieving and processing the treatment response data to determine if the treatment response data show achievement by the subject of a desired endpoint physiological condition, for the primary posture and the primary stimulus, in which the physiological responses to the identified stimulus approach a state of normalcy relative to their corresponding statistical norms and if not, then, under control of the program, repeating processes (i), (ii), (iii), and (iv);
• wherein the protocol promotes thalamocortical pathways within the brain.