Inhalable nanosensors with volatile reporters and uses thereof
AssigneeMassachusetts Institute of Technology
InventorsSangeeta N. Bhatia, Leslie Wan-Gee Chan, Melodi Nilgun Anahtar, Roderick Russell Kunz
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Abstract
In some aspects, the disclosure relates to compositions and method for detection, classification, and treatment of disease or other body status. The methods and compositions may be methods or compositions for identification of pathogenic infections or other diseases in patients using an inhalable nanosensor having a volatile reporter. The disclosure is based, in part, on synthetic biomarkers (e.g., inhalable nanosensors) that are capable of distinguishing (e.g., classifying) different disease or status associated enzymes in a subject by examining the effect of those enzymes on a synthetic volatile reporter.
Claims28
A nanosensor comprising a scaffold linked to a synthetic volatile reporter via an enzymatic substrate, wherein the volatile reporter is capable of being released from the nanosensor when exposed to an enzyme present in a lung of a subject.
Dependencies are inferred from the claim text.