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US 11,053,524 B2Granted
Microorganisms having putrescine productivity and process for producing putrescine using the same
AssigneeCj Cheiljedang Corporation
InventorsKyoung Min Lee, Hee Kyoung Jung, Young Lyeol Yang, Hye Won Um, Chang Gyeom Kim, Hong Xian Li, Su Jin Park, Jong Hyun Yoon, Baek Seok Lee, Sun Young Lee
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Abstract
The present invention relates to a recombinant microorganism capable of producing putrescine, in which the microorganism is modified to have enhanced NCgl2522 activity, thereby producing putrescine in a high yield, and a method for producing putrescine using the microorganism.
Claims11
A method for producing putrescine, comprising:
- (i) culturing a recombinant microorganism having putrescine productivity in a culture medium, and
- (ii) recovering putrescine from the cultured recombinant microorganism or the culture medium,
- wherein the recombinant microorganism is modified to have enhanced activity of a protein having the amino acid sequence of SEQ ID NO:
- 21 or 23 as compared to the activity in the same microorganism without the modification,
- wherein the activity of the protein is enhanced by increasing copy number of a polynucleotide encoding the protein or replacing a promoter of an endogenous polynucleotide encoding the protein with a stronger promoter.
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Dependencies are inferred from the claim text.