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US 11,053,501 B2Granted
Methods of treating neurodegenerative disease by inhibiting N-deacetylase N-sulfotransferase
AssigneeThe Penn State Research Foundation
InventorsScott Brian Selleck, Claire Reynolds-Peterson
Life of this patent
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Abstract
A method of treating a subject suffering from a neurodegenerative disease characterized by insufficient autophagy is provided, the method comprising administering to the subject an effective amount of a composition that inhibits N-deacetylase N-sulfotransferase (NDST). Further provided is a method of identifying a modulator of autophagy.
Claims15
A method of identifying a modulator of autophagy, the method comprising:
- administering a test substance to a cell, the cell comprising an N-deacetylase N-sulfotransferase (NDST) polypeptide and a substrate for NDST, under reaction conditions that promote specific interaction between the NDST polypeptide and the substrate for NDST,
- detecting a change in enzymatic activity of the NDST polypeptide, and
- detecting a corresponding change in autophagy in the cell, thereby identifying the test substance as a modulator of autophagy.
Dependencies are inferred from the claim text.