2-aryl-4-hydroxy-1,3-thiazole derivatives useful as TRPM8-inhibitors in treatment of neuralgia, pain, COPD and asthma

A compound of formula (I):

• wherein
• X is oxygen, sulphur, NH, NOH, or NOMe;
• R is a group selected from the group consisting of 3-fluorophenyl, 4-fluorophenyl, 2-bromophenyl, 3-bromophenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, 2-hydroxyphenyl, 3-hydroxyphenyl, 4-hydroxyphenyl, 3-aminophenyl, 4-aminophenyl, 3-methylaminophenyl, 4-methylaminophenyl, thiophen-2yl, 1,2,4-oxadiazol-3yl and 1,2-oxazol-5yl;
• or R is a group selected from the group consisting of furanyl, pyrrolyl, imidazolyl and pyrazolyl, optionally substituted by one or more substituents selected from the group consisting of:
• hydrogen and
• linear or branched C1-C6 alkyl;
• R1 is a group selected from the group consisting of:
• linear or branched C2-C6 alkyl,
• (CH2)m—OR2, wherein m is an integer between 1 and 3 and R2 is selected from hydrogen and linear C1-C3 alkyl,
• C3-C6 cycloalkyl, and
• N(R3)OR4, wherein R3 and R4 are independently hydrogen or linear or branched C1-C3 alkyl, or a pharmaceutically acceptable salt thereof.