Sulfur derivatives as chemokine receptor modulators
AssigneeAllergan, Inc.
InventorsHaiqing Yuan, Richard L. Beard, Xiaoxia Liu, John E. Donello, Veena Viswanath, Michael E. Garst
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Abstract
The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.
Claims6
A method of modulating chemokine receptors, which comprises administering to a mammal in need thereof, a pharmaceutical composition comprising a therapeutically effective amount of at least one compound of Formula I
- wherein:
- R1 is H or
- R2 is substituted or unsubstituted C1-6 alkyl or substituted or unsubstituted C3-8 cycloalkyl;
- R5 is —S—, —S(O)—, or —S(O)2—;
- R6 is selected from the group consisting of:
- R17 is H;
- R18 is H;
- R7 is H, halogen, —OC1-6 alkyl, or substituted or unsubstituted C1-6 alkyl;
- and
- R8 is H, halogen, or CN;
- with the proviso that R7, R8, R17 and R18 cannot be H in same time.
A method of modulating chemokine receptors, which comprises administering to a mammal in need thereof, a pharmaceutical composition comprising a therapeutically effective amount of at least one compound selected from the group consisting of:
- benzofuran-2-sulfonic acid [2-(3-nitro-benzylsulfanyl)-phenyl]-amide;
- N-[6-(benzylsulfanyl)-1-oxo-2,3-dihydro-1H-inden-5-yl]-1-benzofuran-2-sulfonamide;
- N-[6-(benzylsulfinyl)-1-oxo-2,3-dihydro-1H-inden-5-yl]-1-benzofuran-2-sulfonamide;
- N-[6-(benzylsulfonyl)-1-oxo-2,3-dihydro-1H-inden-5-yl]-1-benzofuran-2-sulfonamide;
- methyl 2-[({2-[(1-benzofuran-2-ylsulfonyl)amino]phenyl}sulfanyl)methyl]benzoate;
- 2-[({2-[(1-benzofuran-2-ylsulfonyl)amino]phenyl}sulfanyl)methyl]benzoic acid;
- methyl 2-[({2-[(1-benzofuran-2-ylsulfonyl)amino]phenyl}sulfinyl)methyl]benzoate;
- 2-[({2-[(1-benzofuran-2-ylsulfonyl)amino]phenyl}sulfinyl)methyl]benzoic acid;
- methyl 2-[({2-[(1-benzofuran-2-ylsulfonyl)amino]phenyl}sulfonyl)methyl]benzoate;
- and
- 2-[({2-[(1-benzofuran-2-ylsulfonyl)amino]phenyl}sulfonyl)methyl]benzoic acid.
Dependencies are inferred from the claim text.