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US 11,045,561 B2Granted
Rotaxane-type probe for molecular imaging
AssigneeUniversity of Rhode Island Board of Trustees
InventorsBrenton DeBoef, Ashvin Fernando
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Abstract
The invention provides a novel method for synthesizing hyperpolarized xenon-129 (HP Xe) biosensors by using pseudo-rotaxane structures of gamma-cyclodextrin. These supramolecular complexes form novel ternary structures in the presence of HP Xe which can be detected via 129Xe MR spectroscopy and imaging techniques. The rotaxane-type complex can be tagged with an affinity label for detecting a target in a biological subject.
Claims20
A supramolecular complex useful as a biosensor, comprising:
- (a) a macrocycle host defining a hydrophobic cavity;
- (b) an axle comprising a molecular chain functionalized with an affinity tag for a target inside a biological subject, wherein the affinity tag is at one or both ends of the molecular chain, and wherein the axle is threaded through the macrocycle cavity;
- and
- (c) a xenon atom, wherein the cavity of the macrocycle host is large enough to accommodate and reversibly encapsulate both a cross section of the axle and the xenon atom at the same time.
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A biosensor comprising:
- (a) a cyclodextrin molecule defining a cavity;
- (b) an alkyl chain molecule functionalized with an affinity tag at one or each of its two ends, wherein the affinity tag has an affinity for a target inside a biological subject, and wherein the alkyl chain molecule is threaded through the cavity in the cyclodextrin;
- and
- (c) a xenon atom in the cavity of the cyclodextrin.
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Dependencies are inferred from the claim text.