Compositions and methods for regulating activity of inhibitor of DNA binding-2 (ID2) protein and for treating ID protein-related diseases
AssigneeThe Trustees of Columbia University in the City of New York
InventorsAntonio Iavarone, Anna Lasorella
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Abstract
The present disclosure provides, in one embodiment, a method of treating or preventing an ID2 protein-related disease in a patient at risk of developing or having such a disease by administering to the patient a composition in an amount and for a time sufficient to increase degradation of HIFα in a cell affected by the ID2 protein-related disease in the patent and/or to decrease half-life of HIFα in the cell affected by the ID2 protein-related disease in the patient, as compared to an untreated cell affected by the ID2 protein-related disease.
Claims8
A method of treating a cancer or a tumor in a patient, the method comprising:
- administering to the patient a composition comprising an isolated Dual-Specificity Tyrosine-Phosphorylation-Regulated Protein Kinase 1 (DYRK1) protein in an amount and for a time sufficient to increase degradation of Hypoxia-Inducible Factor-α (HIFα) in cancer cells or tumor cells in the patient and/or to decrease half-life of HIFα in the cancer cells or tumor cells in the patient.
Dependencies are inferred from the claim text.