Body fluid sampling device-sampling site interface

An arrangement for producing a sample of body fluid from a wound opening created in a skin surface at a sampling site, the arrangement comprising:

• a housing comprising a first opening;
• a first skin interface member disposed in the first opening and removably attached thereto, the first skin interface member comprising a second opening;
• a second skin interface member configured to be disposed in the first opening and removably attached thereto;
• and
• at least one skin-penetration member comprising a penetrating end aligned with the second opening;
• wherein the first skin interface member is exchangeable with the second skin interface member, the first skin interface member configured to provide a first penetration depth of the skin-penetration member into the skin surface, and the second skin interface member configured to provide a second penetration depth of the skin-penetration member into the skin surface.