Low molecular weight modulators of the cold menthol receptor TRPM8 and use thereof

A substance, wherein the substance is a modulator for use as a mediator of the TRMP8 receptor and is a compound selected from the group consisting of:

• a) compounds of the general formula IA:
• in which:
• a is a C—C single bond or a C—C double bond,
• W is N or CH,
• X and Z, independently of one another, are —O—, —S—, —NR18—, —S(═O)—, or —S(═O)2—,
• Y is selected from straight-chain or branched C1-C8-alkylene groups which optionally carry 1, 2, 3 or 4 identical or different substituents which are selected from NH2, OH, SH, halogen or straight-chain or branched C1-C6-alkoxy groups;
• or X—Y—Z, together with the carbon atom to which they are bonded, form a keto group,
• R11 to R18, independently of one another, are selected from:
• H;
• aryl;
• straight-chain or branched, optionally mono- or polyunsaturated C1-C6-alkyl groups which optionally carry 1, 2, 3 or 4 identical or different substituents which are selected from oxo groups (═O), NH2, OH, SH, halogen or straight-chain or branched C1-C6-alkoxy groups;
• and straight-chain or branched C1-C6-alkyloxy groups which optionally carry 1, 2, 3 or 4 identical or different substituents which are selected from NH2, OH, SH, halogen or straight-chain or branched C1-C6-alkoxy groups;
• or
• R11-R12, together with the carbon atoms to which they are bonded, form a 4-, 5-, 6- or 7-membered, saturated or mono- or polyunsaturated, carbocyclic ring which optionally carries 1, 2, 3, 4 or 5 identical or different substituents which are selected from straight-chain or branched C1-C6-alkyl groups, and oxo groups (═O);
• or
• b) compounds of the general formula IB;
• in which:
• b is a C—C single bond or a C—C double bond,
• V is —CH2— or carbonyl;
• W, X, Y, Z and R11 to R18 have the meanings given above;
• U is —CH2— or —O—;
• and
• where U and V are not simultaneously —CH2—;
• or
• c) of the general formula IC:
• a, X, Y, Z and R11 to R18 have the meanings given above;
• U is —CH2— or a chemical bond;
• and V is —CH2— or carbonyl;
• where U and V are optionally not simultaneously —CH2—;
• wherein the modulator is not