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AssigneesThomas Jefferson University, The United States of America as represented by the Secretary, Department of Health and Human Service, University of Maryland
InventorsReed F. Johnson, Matthias Schnell, Lisa E. Hensley, Christoph Wirblich, Christopher M. Coleman, Matthew B. Frieman
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The present disclosure provides methods and compositions for inducing an immune response that confers dual protection against infections by either or both of a rabies virus and a coronavirus, and/or which can be used therapeutically for an existing infection with rabies virus and/or a coronavirus to treat at least one symptom thereof and/or to neutralize or clear the infecting agents. In particular, the present disclosure provides a recombinant rabies virus vector comprising a nucleotide sequence encoding at least one coronavirus immunogenic glycoprotein fragment, as well as pharmaceutical compositions comprising the vaccine vectors.
A recombinant rabies virus vector comprising a nucleotide sequence encoding at least one immunogenic protein, wherein the at least one immunogenic protein comprises an amino acid sequence selected from the group consisting of SEQ ID NO:
A multivalent composition effective to induce an immune response against both rabies and at least one coronavirus, comprising a recombinant rabies virus vector that expresses at least one immunogenic protein, wherein the at least one immunogenic protein comprises an amino acid sequence selected from the group consisting of SEQ ID NO:
A virus composition comprising an attenuated recombinant rabies virus vector which expresses a MERS-CoV glycoprotein or a fragment thereof, wherein the virus composition induces an immune response against both a rabies virus infection and a MERS-CoV infection, and wherein the MERS-CoV glycoprotein or a fragment thereof comprises an amino acid sequence selected from the group consisting of SEQ ID NO:
A method of inducing an immune response against a coronavirus and/or a rabies virus in a subject, comprising administering to the subject a therapeutically effective amount of a multivalent composition comprising a recombinant rabies virus vector that expresses at least one immunogenic glycoprotein or fragment thereof from at least one coronavirus
A method of inducing neutralizing antibodies against coronavirus and/or a rabies virus in a subject infected with or having been exposed to either or both of said viruses, comprising administering to the subject a therapeutically effective amount of a multivalent composition comprising a recombinant rabies virus vector that expresses at least one immunogenic protein, wherein the at least one immunogenic protein
A method of treating a subject infected with a coronavirus and/or a rabies virus, comprising administering to the subject a therapeutically effective amount of a multivalent composition comprising a recombinant rabies virus vector that expresses at least one immunogenic protein, wherein said composition induces an effective immune response against one or both of said viruses
A live, replication-competent, rabies virus based vector expressing at least one glycoprotein MERS-Cov or SARS-Cov or fragment thereof, wherein the vector has the nucleotide sequence of SEQ ID NO:
Dependencies are inferred from the claim text.