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US 11,040,932 B2Granted
Synthesis of cannabigerol
AssigneeTreehouse Biotech, Inc.
InventorsThomas Smeltzer, Robert Davis, Sean Colvin, Jacob Black
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Abstract
Multiple methods of synthesizing cannabigerol are presented. Combining olivetol with geraniol derivatives are provided. Cross-coupling methods of combing functionalized resorcinols are provided. Useful intermediates are formed during such cross-coupling steps.
Claims4
A method comprising:
- providing a first compound having the structure
- combining the first compound with a second compound having the structure:
- in a solvent to form a solution;
- adding a suitable cross coupling metal catalyst to the solution to form an active mixture;
- and
- reacting the active mixture to form a reacting mixture, wherein the reacting mixture contains a detectable amount of a third compound having the structure:
- wherein R1 and R3 each are selected from the group consisting of:
- SEM, MOM, Me, Bn, TBS, and hydrogen;
- wherein Z is selected from the group consisting of:
- boronate group, boronic acid, iodide, and bromide;
- and
- wherein Y is selected from the group consisting of:
- iodide, bromide, a boronate group, and boronic acid group.
10 more elements
Dependencies are inferred from the claim text.