Conjugates of kinase inhibitors and cyanine dyes

A conjugate of Formula (Ia):

• or a pharmaceutically acceptable salt thereof, wherein:
• L is selected from optionally substituted C1-10 alkyl, and optionally substituted heteroC1-10 alkyl;
• K is selected from:
• each — is a covalent bond;
• X is halogen;
• Z is one or more anions to achieve electrical neutrality;
• R2 and R3 combine to form a five- or six-membered ring, wherein the five- or six-membered ring is optionally substituted and optionally fused to an aryl or heteroaryl ring;
• R4 and R5 independently are hydrogen, optionally substituted aliphatic, optionally substituted heteroaliphatic, optionally substituted aryl, or optionally substituted heteroaryl;
• R6 and R7 are independently hydrogen, or aliphatic, or combine to form a five- or six-membered carbocyclic or heterocyclic ring;
• R8 and R9 independently are hydrogen, optionally substituted aliphatic, optionally substituted heteroaliphatic, optionally substituted aryl, or optionally substituted heteroaryl;
• R10 and R11 combine to form a five- or six-membered ring, wherein the five- or six-membered ring is optionally substituted and optionally fused to an aryl or heteroaryl ring;
• and
• R12 is optionally substituted aliphatic, or optionally substituted heteroaliphatic.