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US 11,034,744 B2Granted
CRP capture/detection of gram positive bacteria
AssigneePresident and Fellows of Harvard College
InventorsAlexander L. Watters, Donald E. Ingber, Mark J. Cartwright, Michael Super, Martin Rottman, Evangelia Murray, Brendon Dusel
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Abstract
Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.
Claims13
A microbe-targeting molecule comprising:
- a. at least one first domain comprising at least a portion of a c-reactive protein (CRP);
- b. at least one second domain comprising at least a portion of a domain selected from the group consisting of:
- (i) Fc region of an immunoglobulin;
- (ii) microbe-binding domain of a microbe-binding protein, wherein the microbe-binding protein is not CRP;
- (ii) neck region of a lectin;
- (iv) a detectable label;
- (v) domain for conjugation to surface of a carrier scaffold;
- (vi) pattern recognition receptor domain of CRP;
- and
- (vii) any combinations of (i)-(vi);
- and
- a linker conjugating the first and second domains, and
- wherein the molecule is a multimeric molecule.
10 more elements
Dependencies are inferred from the claim text.