7-dehydrocholesterol derivatives and methods using same

A method of inhibiting angiogenesis in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of at least one compound of formula (I) or a salt or solvate thereof:

• wherein:
• R1 is CR5 or N;
• R3 is selected from the group consisting of —O(CR5)nR6, —OC(═O)(CR5)nR6, —OC(═O)(CR5)nOR5, and —OC(═O)C(R5)═C(R5)2;
• R2 is selected from the group consisting of O, S, C(R4)2, and N(R4);
• each occurrence of R4 is independently selected from the group consisting of H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, OR5, and N(R5)2;
• each occurrence of R5 is independently selected from the group consisting of H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, and substituted heteroarylalkyl;
• R6 is selected from the group consisting of F, Cl, Br, I, mesyl, tosyl, —OSi(R5)3, —C(═O)OR5, and —C(═O)R5;
• the dotted line is a single or double bond;
• and
• n is an integer ranging from 1 to 10.