Histone acetyltransferase activators and uses thereof
AssigneeThe Trustees of Columbia University in the City of New York
InventorsYan Feng, Mauro Fa, Ottavio Arancio, Shixian Deng, Donald W. Landry, Yitshak Francis
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Abstract
The invention provides for a method for screening compounds that bind to and modulate a histone acetyltransferase protein. The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a HAT-activating compound to a subject.
Claims11
A method for treating cancer in a subject, the method comprising administering to a subject a therapeutic amount of a pharmaceutical composition comprising a compound having the following structure:
- or a pharmaceutically acceptable salt or hydrate thereof.
Dependencies are inferred from the claim text.