Process for the cyclopropanation of olefins using N-methyl-N-nitroso compounds
AssigneeGivaudan SA
InventorsFridtjof Schröder, Marcel Steck
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Abstract
A process of converting a carbon-carbon double bond on a substrate into a cyclopropane ring, which method comprises the step of treating the substrate with a N-alkyl-N-nitroso compound, a transition metal catalyst and an aqueous base, wherein the N-alkyl-N-nitroso compound is formed by reacting an alkyl amine with an alkali metal nitrite in the presence of a mono-basic or di-basic acid, or a mixture thereof, and wherein the N-alkyl-N-nitroso compound is not distilled before it is mixed with the substrate, catalyst and base.
Claims7
A process of converting a carbon-carbon double bond on a substrate into a cyclopropane ring, the process comprising treating the substrate with (N-methyl-N-nitroso)-4-amino-4-methyl-2-pentanone, a transition metal catalyst and an aqueous base, and thereby forming the cyclopropane ring, wherein the (N-methyl-N-nitroso)-4-amino-4-methyl-2-pentanone is formed by reacting (N-methyl)-4-amino-4-methyl-2-pentanone with an alkali metal nitrite in the presence of formic acid and wherein the (N-methyl-N-nitroso)-4-amino-4-methyl-2-pentanone N is not distilled before it is mixed with the substrate, catalyst and base.
Dependencies are inferred from the claim text.