Oral dosage form

A method of treating the oral cavity of a person having gingivitis or periodontitis with an orodispersible tablet, wherein the orodispersible tablet consists of a

• (a) mucoadhesive active composition in the form of granules having a diameter of from 50 to 1000 μm and, consisting of
• (a1) a mucoadhesive polymer selected from group consisting of polyacrylic acid, hypromellose and chitosan, and
• (a2) a probiotic which is selected from the group consisting of Lactobacillus plantarum 299V, Lactobacillus plantarum Heal 9, Lactobacillus plantarum Heal 52A, Lactobacillus plantarum Heal 99, Lactobacillus fermentum 35 D, Lactobacillus fermentum GOS 51, Lactobacillus plantarum GOS 42, and Lactobacillus paracasei GOS 63, and
• (a3) a binder selected from the group consisting of acacia gum, gelatin, polyvinylpyrrolidone, copovidone, polyvinyl alcohol, starch, alginate derivatives, sorbitol, sugars, tragacanth, methylcellulose, hydroxypropylmethylcellulose, sodium carboxymethylcellulose, hydroxypropylcellulose, maltodextrin, ammonio methacrylate copolymer, methacrylic acid methyl methycrylate copolymer, basic butylated methacrylate copolymer, methacrylic acid ethyl acrylate copolymer, cellacefate, hypromellose acetate succinate, hypromellose phthalate, polyvinyl acetate phthalate, polyvinyl alcohol-polyethylene glycol copolymer, and shellac in an amount of from 0.5 to 20 wt. %, based on the weight of the probiotic, and
• (b) at least one disintegrant selected from the group consisting of croscarmellose sodium, calcium carboxymethyl cellulose, crospovidone, sodium starch glycolate, alginic acid, calcium alginate, bentonite, cellulose, and guar galactomannan in an amount of from about 1 to about 15 wt. % based on the weight of the orodispersible tablet and;
• wherein the method consists of:
• mixing the components (a) and (b) into a dry homogenous mixture wherein the ratio between the mucoadhesive polymer and the probiotic is from abut 10:1 to about 1:50 and compressing the mixture to form an orodispersible tablet
• applying the orodispersible tablet to the oral cavity of the person having gingivitis or periodontitis, and
• allowing the orodispersible tablet to dissolve completely in the oral cavity within 3 minutes, and wherein the probiotic is retained on the oral mucosa of the oral cavity of the person having gingivitis or periodontitis by the mucoadhesive polymer for a period sufficient to treat the gingivitis or periodontitis.