# US 11,029,268 B2 · Hybrid NMR and OCT system

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- Number: US 11,029,268 B2
- Document ID: US11029268B2
- Status: Granted
- Kind: B2
- Application number: 16/636,709
- Filed: 2018-08-02
- Published: 2020-07-30
- Granted: 2021-06-08
- Earliest claimed: 2017-08-06
- Assignees: Clear-Cut Medical Ltd.
- Applicants: Clear-Cut Medical Ltd.
- Inventors: Armin Schon
- Web page: https://patentgrep.com/patent/US11029268B2

## CPC

- G01N 24/08: by using nuclear magnetic resonance (G01N24/12 takes precedence)
- A61B 5/0035: {adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography}
- A61B 5/055: involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
- G01B 9/02091: Tomographic interferometers, e.g. based on optical coherence
- G01R 33/307: {specially adapted for moving the sample relative to the MR system, e.g. spinning mechanisms, flow cells or means for positioning the sample inside a spectrometer}
- G01R 33/4808: {Multimodal MR, e.g. MR combined with positron emission tomography [PET], MR combined with ultrasound or MR combined with computed tomography [CT]}
- G01R 33/5601: {involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent}
- G01R 33/56341: {Diffusion imaging}
- G01R 33/448: {Relaxometry, i.e. quantification of relaxation times or spin density (G01R33/50 takes precedence)}
- G01R 33/465: applied to biological material, e.g. in vitro testing
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- G01B: MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
- G01R: MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES (indicating correct tuning of resonant circuits H03J3/12)

## Abstract

A system includes an NMR system (10) including a coil (18) and a magnet (12) capable of obtaining NMR information from a tissue (17) and an MRI processor (19) for creating a pixel map of the tissue (17) from the NMR information. The system also includes an OCT system (20) with an OCT processor (21) capable of creating an optical coherence tomography of the tissue (17). A tissue sample holder (16) is coupled to a manipulator to move the tissue sample holder (16) to the NMR system (10) for creating the pixel map of the tissue (17) and to move the tissue sample holder (16) to the OCT system (20) for creating the optical coherence tomography of the tissue (17).

## Claims

### Claim 1

A system comprising:
a nuclear magnetic resonance (NMR) system comprising a coil and a magnet capable of obtaining NMR information from a tissue and a magnetic resonance imaging (MRI) processor for creating a pixel map of said tissue from said NMR information;
an optical coherence tomography (OCT) system comprising an OCT processor capable of creating an optical coherence tomography of the tissue;
a tissue sample holder;
a manipulator configured to cause relative movement between said tissue sample holder and said NMR system and said OCT system for creating the pixel map of said tissue and for creating the optical coherence tomography of the tissue; and
a hybrid processor in communication with said MRI processor and said OCT processor, wherein said hybrid processor is configured to command said OCT processor to cause said OCT system to scan pixels considered suspicious of having pathologically irregular or abnormal cells by said MRI processor.

### Claim 2 (depends on 1)

The system according to claim 1, further comprising a camera configured to generate an image of the tissue inside said tissue sample holder.

### Claim 3 (depends on 1)

The system according to claim 1, wherein said NMR system uses T1 or T2 measurement, T1 or T2 measurements enhanced with contrast material, diffusion-weighted measurement, or a combination thereof.

### Claim 4

A method for real-time tissue analysis comprising:
using a nuclear magnetic resonance (NMR) system comprising a coil and a magnet capable of obtaining NMR information from a tissue and a magnetic resonance imaging (MRI) processor for creating a pixel map of said tissue from said NMR information; an optical coherence tomography (OCT) system comprising an OCT processor capable of creating an optical coherence tomography of the tissue; a tissue sample holder; and a manipulator configured to cause relative movement between said tissue sample holder and said NMR system and said OCT system for creating the pixel map of said tissue and for creating the optical coherence tomograph of the tissue;
and further comprising using said NMR system to create a pixel map of tissue from said NMR information, said pixel map having suspicious pixels considered suspicious of having pathologically irregular or abnormal cells by said MRI processor, and using said OCT system to scan said suspicious pixels and create an optical coherence tomography image of said suspicious pixels.