Vascular constructs
AssigneeWake Forest University Health Sciences
InventorsSang Jin Lee, James J. Yoo, Young Min Ju, Anthony Atala
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Abstract
The invention is directed to products and methods for preparing self-seeding vascular constructs generated as a bi-layered electrospun matrices, conjugated with EPC-specific antibodies and anti-thrombogenic agents on the inner surfaces of their lumens.
Claims44
A self-seeding bi-layered vascular graft comprising an electrospun matrix having a tubular shape with an outside surface and a lumen that defines an inside surface and a three-dimensional ultrastructure of interconnected fibers with pores, the matrix further comprises an inner region, in which the average pore size is less than 1 micron and wherein the inner region of the tubular matrix comprises fibers having an average diameter between 100 and 900 nanometers and an outer region, in which the average pore size is greater than 1 micron and wherein one or more EPC-specific antibodies and one or more anti-thrombogenic agents are conjugated to the lumen.
A self-seeding bi-layered vascular graft comprising an electrospun matrix having a tubular shape with an outside surface and a lumen that defines an inside surface and a three-dimensional ultrastructure of interconnected fibers with pores, the matrix further comprises an inner region, in which the average pore size is less than 1 micron and an outer region, in which the average pore size is greater than 1 micron and wherein the outer region of the tubular matrix comprises fibers having an average fiber size of between about 1 micron and about 5 microns and wherein one or more EPC-specific antibodies and one or more anti-thrombogenic agents are conjugated to the lumen.
Dependencies are inferred from the claim text.