# US 11,028,405 B2 · Nucleotide sequences and corresponding polypeptides conferring modulated growth rate and biomass in plants grown in saline and oxidative conditions

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- Number: US 11,028,405 B2
- Document ID: US11028405B2
- Status: Granted
- Kind: B2
- Application number: 16/750,667
- Filed: 2020-01-23
- Published: 2020-05-28
- Granted: 2021-06-08
- Earliest claimed: 2006-03-14
- Assignees: Ceres, Inc.
- Applicants: Ceres, Inc.
- Inventors: Fasong Zhou; Kenneth A. Feldmann; Julissa Sosa
- Web page: https://patentgrep.com/patent/US11028405B2

## CPC

- C12N 15/8273: {for drought, cold, salt resistance}
- C07K 14/415: from plants
- C12N 15/8271: {for stress resistance, e.g. heavy metal resistance}
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

## Abstract

The present invention relates to isolated nucleic acid molecules and their corresponding encoded polypeptides able confer the trait of improved plant size, vegetative growth, growth rate, seedling vigor and/or biomass in plants challenged with saline and/or oxidative stress conditions. The present invention further relates to the use of these nucleic acid molecules and polypeptides in making transgenic plants, plant cells, plant materials or seeds of a plant having plant size, vegetative growth, growth rate, seedling vigor and/or biomass that are improved in saline and/or oxidative stress conditions with respect to wild-type plants grown under similar conditions.

## Claims

### Claim 1

A method of producing a plant having increased tolerance to salinity or increased tolerance to oxidative stress, said method comprising growing plant cells transformed with an exogenous nucleic acid, said exogenous nucleic acid comprising a heterologous promoter operably linked to a nucleotide sequence encoding a polypeptide, wherein said polypeptide has 95 percent or greater amino acid sequence identity to the amino acid sequence of SEQ ID NO:86, and wherein overexpression of said polypeptide in a transformed plant grown from said transformed plant cells results in an increased level of tolerance to salinity or oxidative stress as compared to the corresponding level in tolerance to salinity or oxidative stress of a control plant of the same species cultivated under the same conditions that does not comprise said exogenous nucleic acid.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the nucleotide sequence encodes a polypeptide having 97 percent or greater amino acid sequence identity to the amino acid sequence of SEQ ID NO:86.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the nucleotide sequence encodes a polypeptide having 98 percent or greater amino acid sequence identity to the amino acid sequence of SEQ ID NO:86.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the nucleotide sequence encodes a polypeptide having the amino acid sequence as set forth in SEQ ID NO:86.