# US 11,028,338 B2 · Method for making full use of Lippia origanoides

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- Number: US 11,028,338 B2
- Document ID: US11028338B2
- Status: Granted
- Kind: B2
- Application number: 16/474,470
- Filed: 2017-12-13
- Published: 2019-11-14
- Granted: 2021-06-08
- Earliest claimed: 2016-12-27
- Assignees: Universidad Industrial de Santander
- Applicants: Universidad Industrial De Santander
- Inventors: Elena Stashenko; Diego Camilo Duran Garcia; Jairo Rene Martinez Morales; Yuri Cordoba Campo; Anderson Julian Arias Velandia; Jesica Julieth Mejia Medina; Camilo Andres Tavera Reyes
- Web page: https://patentgrep.com/patent/US11028338B2

## CPC

- C11B 9/025: {Recovery by solvent extraction}
- A01N 65/08: Magnoliopsida [dicotyledons]
- A23L 33/105: Plant extracts, their artificial duplicates or their derivatives
- A61K 8/347: {Phenols}
- A61K 8/498: {having 6-membered rings or their condensed derivatives, e.g. coumarin}
- A61K 8/602: {Glycosides, e.g. rutin}
- A61K 8/9789: Magnoliopsida [dicotyledons]
- A61K 31/05: Phenols {(cannabinoids A61K31/658)}
- A61Q 17/02: containing insect repellants
- A61Q 19/00: Preparations for care of the skin
- B01D 3/38: Steam distillation
- B01D 3/40: Extractive distillation
- B01D 9/0004: {cooling by heat exchange (by evaporation of components of the mixture to be separated B01D9/0013; refrigeration machines F25B)}
- B01D 11/0203: {with a supercritical fluid}
- B01D 11/0284: {Multistage extraction}
- B01D 11/0288: {Applications, solvents}
- B01D 11/0296: {Condensation of solvent vapours (condensation in general B01D5/00)}
- C05F 11/00: Other organic fertilisers
- C07C 7/04: by distillation
- C07C 7/10: by extraction, i.e. purification or separation of liquid hydrocarbons with the aid of liquids
- C07C 37/004: {by obtaining phenols from plant material or from animal material}
- C10L 5/44: on vegetable substances
- C10L 5/445: {Agricultural waste, e.g. corn crops, grass clippings, nut shells or oil pressing residues}
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- C10L 2200/0469: Renewables or materials of biological origin
- C10L 2290/543: Distillation, fractionation or rectification for separating fractions, components or impurities during preparation or upgrading of a fuel
- C10L 2290/544: Extraction for separating fractions, components or impurities during preparation or upgrading of a fuel
- Y02E 50/10: Biofuels, e.g. bio-diesel
- Y02E 50/30: Fuel from waste, e.g. synthetic alcohol or diesel
- C11B: PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES (drying-oils C09F)
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- B01D: SEPARATION (separating solids from solids by wet methods B03B, B03D; by pneumatic jigs or tables B03B; by other dry methods B07; magnetic or electrostatic separation of solid materials from solid materials or fluids, separation by high-voltage electric fields B03C; centrifuges, vortex apparatus B04; presses per se for squeezing-out liquid from liquid-containing material B30B9/02; treatment of water C02F, e.g. softening by ion-exchange C02F1/42; {arrangements of air intake cleaners in gas turbine plants F02C7/05} ; arrangements or mounting of filters in air-conditioning, air-humidification or ventilation F24F13/28)
- C05F: ORGANIC FERTILISERS NOT COVERED BY SUBCLASSES C05B, C05C, e.g. FERTILISERS FROM WASTE OR REFUSE
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C10L: FUELS NOT OTHERWISE PROVIDED FOR; NATURAL GAS; SYNTHETIC NATURAL GAS OBTAINED BY PROCESSES NOT COVERED BY SUBCLASSES C10G OR C10K; LIQUIFIED PETROLEUM GAS; USE OF ADDITIVES TO FUELS OR FIRES; FIRE-LIGHTERS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- Y02E: REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION

## Abstract

The present invention relates to a method for extracting, separating and purifying compounds of interest obtained from essential oils and plant extracts which is continuously held.

## Claims

### Claim 1

A process for extracting compounds of interest from Lippia origanoides plants comprising the steps of:
step a) reducing a plant material of Lippia origanoides plant to a particle size between 0.5 cm and 5 cm;
step b) loading the reduced plant material from step a) into a distillation equipment;
step c) subjecting the loaded plant material from step b) to a first distillation thereby producing distillates;
step d) separating said distillates into a light fraction and a heavy fraction;
step e) drying a residue of the distilled plant material from step c); and
step f) subjecting said dried residue from step e) to an extraction with solvents to recover other compounds;
wherein the process is performed continuously.

### Claim 2 (depends on 1)

The process according to claim 1, wherein the first distillation of step c) is conducted by a steam distilling process.

### Claim 3 (depends on 1)

The process according to claim 1, wherein the first distillation of step c) is conducted by a hydrodistillation process.

### Claim 4 (depends on 1)

The process according to claim 1, wherein a light fraction mixed with water is separated during the first 10-30 minutes of step c).

### Claim 5 (depends on 4)

The process according to claim 4, wherein the light fraction mixed with water comprises a volatile fraction enriched with phenylpropanes p-cymene and gamma-terpinene precursors.

### Claim 6 (depends on 4)

The process according to claim 4, wherein the light fraction obtained in step d) is combined with the light fraction mixed with water separated from step c).

### Claim 7 (depends on 1)

The process according to claim 1, wherein said heavy fraction is loaded into a fractionating column.

### Claim 8 (depends on 1)

The process according to claim 1, wherein said heavy fraction is subjected to a crystallization process.

### Claim 9 (depends on 1)

The process according to claim 1, wherein step f) is conducted with a hydro alcoholic mixture.

### Claim 10 (depends on 1)

The process according to claim 1, wherein step f) is conducted with supercritical carbon dioxide and ethanol.

### Claim 11 (depends on 1)

The process according to claim 1, wherein a hydrolate obtained in step c) is recirculated during the first distillation process of step c), and at the end of said first distillation process of step c) any hydrolate left is collected as a by-product used to manufacture air fresheners, biopesticides, or repellents.

### Claim 12 (depends on 1)

The process according to claim 1, wherein a residual of said dried plant material obtained from extraction in step f) is used as a by-product for composting or as biofuel used as a source of energy for the process.