# US 11,028,140 B2 · Osteogenic biomaterial

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 11,028,140 B2
- Document ID: US11028140B2
- Status: Granted
- Kind: B2
- Application number: 15/512,964
- Filed: 2015-09-22
- Published: 2017-10-12
- Granted: 2021-06-08
- Earliest claimed: 2014-09-22
- Assignees: Northeast Ohio Medical University
- Applicants: Northeast Ohio Medical University
- Inventors: Fayez Safadi
- Web page: https://patentgrep.com/patent/US11028140B2

## CPC

- C07K 14/51: Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
- A61K 9/0024: {Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue (compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L)}
- A61K 38/1709: {from mammals}
- A61K 47/36: Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61L 24/0015: {Medicaments; Biocides}
- A61L 24/0042: {Materials resorbable by the body}
- A61L 27/24: Collagen
- A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)}
- A61L 27/58: Materials at least partially resorbable by the body
- A61L 31/148: {Materials at least partially resorbable by the body}
- A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)}
- A61P 19/00: Drugs for skeletal disorders
- A61F 2002/30062: {(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive}
- A61K 31/00: Medicinal preparations containing organic active ingredients
- A61K 47/34: Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers (A61K47/10 takes precedence)
- A61L 2300/25: Peptides having up to 20 amino acids in a defined sequence
- A61L 2300/412: Tissue-regenerating or healing or proliferative agents
- A61L 2430/02: for reconstruction of bones; weight-bearing implants
- C07K 2319/00: Fusion polypeptide
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)

## Abstract

A composition for enhancing bone tissue repair or regeneration is described. The composition includes osteoactivin or an active peptide fragment thereof and a biocompatible material. Osteogenic orthopedic devices including the osteoactivin-containing composition are also described. The devices and compositions can be used in methods for enhancing bone tissue repair or regeneration by contacting a site in need of bone repair or regeneration in a subject with the osteoactivin-containing composition.

## Claims

### Claim 1

A composition for enhancing bone tissue repair or regeneration, comprising:
an active peptide fragment of osteoactivin having the amino acid sequence of SEQ ID NO: 1, and
a biocompatible polymer; wherein the biocompatible polymer is covalently bound to the active peptide fragment of osteoactivin.

### Claim 2 (depends on 1)

The composition of claim 1, wherein the biocompatible polymer is a polylactide polymer.

### Claim 3 (depends on 2)

The composition of claim 2, wherein the biocompatible polymer is a functionalized polylactide polymer.

### Claim 4 (depends on 1)

The composition of claim 1, wherein the biocompatible polymer is configured as a tissue scaffold.

### Claim 5 (depends on 1)

The composition of claim 1, wherein the biocompatible polymer is selected from the group consisting of collagen, chitosan, a polylactide polymer, a functionalized polylactide polymer, and a polylactic acid-poly(ethylene glycol) block copolymer.

### Claim 6 (depends on 1)

An osteogenic orthopedic device, comprising:
An implantable orthopedic device, coated with the composition of claim 1 and a biocompatible material.

### Claim 7 (depends on 6)

The implantable orthopedic device of claim 6, wherein the orthopedic device is a bone fixation member having bone interfaces or outer bone contacting surfaces.

### Claim 8 (depends on 1)

A method for enhancing bone tissue repair or regeneration, comprising:
contacting a site in need of bone repair or regeneration in a subject with the composition of claim 1, and a biocompatible material.

### Claim 9 (depends on 8)

The method of claim 8, wherein the composition is in an injectable form, and wherein the step of contacting the site comprises administering the composition by injection to the site in need of bone repair or regeneration.

### Claim 10 (depends on 8)

The method of claim 8, wherein the step of contacting the site comprises surgically implanting the composition.

### Claim 11 (depends on 8)

The method of claim 8, wherein the site in need of bone repair or regeneration is a dental site.

### Claim 12 (depends on 8)

The method of claim 8, wherein the biocompatible material is configured as a tissue scaffold.

### Claim 13 (depends on 8)

The method of claim 8, wherein the biocompatible material is collagen or chitosan.