Back to results
US 11,028,103 B2Granted
Derivatized 3-styryl-cephalosporins
AssigneeGladius Pharmaceuticals Corporation
InventorsLarry D. Sutton, Sophia Yu
Life of this patent
Estimating the term…
Abstract
Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the invention are designed such that on cleavage of the beta-lactam ring reactive moieties are generated which can inactivate beta-lactamase. Also provided are methods of making beta-lactamase inhibitors and beta-lactam antibiotics exhibiting such inhibition. Additionally provided are pharmaceutical compositions for treatment or prevention of bacterial infections and methods of treatment of such infections.
Claims11
A compound of formula:
- or pharmacologically acceptable salts thereof wherein:
- R2, R3, R4, R5, R7, R8 and R16 are hydrogen;
- R6 is hydrogen or NO2;
- L is —CH2;
- n is 0 or an integer number ranging from 1 to 5;
- Z is —S—;
- X is
- wherein,
- each R20 independently is selected from hydrogen or two adjacent R20 together with the atoms to which they are attached form a 5-6 member carbocyclic or heterocyclic ring which may contain one or more double bonds or be aromatic;
- and
- R1 is a pharmacologically acceptable functional group which is a functionalized imine selected from the group consisting of
- wherein R9 is hydrogen and R10 is C1-C6 alkyl or C1-C6 carboxylic acid.
9 more elements
Dependencies are inferred from the claim text.