# US 11,028,102 B2 · Methods of using 1-O-acetylbritannilatone spiro aryl isoxazoline compounds

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- Number: US 11,028,102 B2
- Document ID: US11028102B2
- Status: Granted
- Kind: B2
- Application number: 16/805,772
- Filed: 2020-02-29
- Published: 2020-06-25
- Granted: 2021-06-08
- Earliest claimed: 2017-12-15
- Assignees: Xi'an Taikomed Pharmaceutical Technology Co., Ltd.
- Applicants: Xi'an Taikomed Pharmaceutical Technology Co., Ltd.
- Inventors: Yonghong Tang; Minghui Chang; Huafeng Qi; Chengyuan Liang; Xingke Ju; Lei Tian; Yuzhi Liu; Han Li
- Web page: https://patentgrep.com/patent/US11028102B2

## CPC

- C07D 498/10: Spiro-condensed systems
- A61P 11/06: Antiasthmatics
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C07D 495/04: Ortho-condensed systems
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A method of inhibiting leukotriene include: administrating a therapeutically effective amount of a compound of chemical formula I or II or a pharmaceutical acceptable salt thereof to a subject, R1 is OH or OAc; X is C or N; and R2 is H, alkyl, alkoxy, benzyloxy, haloalkyl, OH, CN, NO2, or halogen, provided that when X is N, R2 is nil.

## Claims

### Claim 1

A method of inhibiting leukotriene comprising:
administrating a therapeutically effective amount of a compound of chemical formula I or II or a pharmaceutical acceptable salt thereof to a subject,
wherein R1 is OH or OAc; X is C or N; and R2 is H, alkyl, alkoxy, benzyloxy, haloalkyl, OH, CN, NO2, or halogen, provided that when X is N, R2 is nil.

### Claim 2 (depends on 1)

The method of claim 1, wherein X is C and R2 is H, F, Cl, Br, CN, CH3, OCH3, NO2 or OH.