# US 11,028,090 B2 · [1,2,4]Triazolo[4,3-a]quinoxaline derivative, method for preparing same, and pharmaceutical composition for preventing or treating BET protein-related diseases, containing same as active ingredient

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- Number: US 11,028,090 B2
- Document ID: US11028090B2
- Status: Granted
- Kind: B2
- Application number: 16/480,908
- Filed: 2018-01-25
- Published: 2020-02-06
- Granted: 2021-06-08
- Earliest claimed: 2017-01-26
- Assignees: Dong Wha Pharm. Co., Ltd.; Korea Research Institute of Chemical Technology
- Applicants: Dong Wha Pharm. Co., Ltd.; Korea Research Institute of Chemical Technology
- Inventors: Kwangho Lee; Gildon Choi; Imran Ali; Joo Yun Lee; Jin Soo Lee; Whui Jung Park; Yong Tae Kim; Seung Hwan Kim; Jung Hwan Kim; Jae-Kyung Lim
- Web page: https://patentgrep.com/patent/US11028090B2

## CPC

- C07D 487/04: Ortho-condensed systems
- A61K 31/4196: 1,2,4-Triazoles
- A61K 31/4985: Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
- A61P 35/00: Antineoplastic agents
- C07D 519/00: Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Provided are a novel [1,2,4]triazolo[4,3-a]quinoxaline derivative, a method for preparing the same, and a pharmaceutical composition for preventing or treating bromodomain extra-terminal (BET) protein-related diseases including cancer and autoimmune diseases, containing the same as an active ingredient.

## Claims

### Claim 1

A compound represented by formula 1, an optical isomer thereof or a pharmaceutically acceptable salt thereof:
wherein,
R1 is C1-20 straight or branched alkyl nonsubstituted or substituted with one or more halogens, or C6-20 aryl;
R2 is hydrogen, C1-20 straight or branched alkyl, or C1-20 straight or branched alkoxy;
R3 is hydrogen, nitro, halogen, nonsubstituted or substituted C1-20 straight or branched alkyl, nonsubstituted or substituted C1-20 straight or branched alkoxy, 5-10 membered heteroaryl nonsubstituted or substituted with one or more methyl groups containing one or more heteroatoms selected from the group consisting of N, O and S,
which forms 6 membered cycloalkyl containing one or more heteroatoms selected from the group consisting of S and O along with R4,
wherein, the substituted C1-20 straight or branched alkyl and the substituted C1-20 straight or branched alkoxy can be independently substituted with one or more substituents selected from the group consisting of halogen, C1-3 straight or branched alkoxy, 5-10 membered heterocycloalkyl containing one or more heteroatoms selected from the group consisting of N, O and S, and C6-10 aryl nonsubstituted or substituted with one or more nitro groups,
A1 is hydrogen, or C1-20 straight or branched alkyl,
B1 and B2 are independently hydrogen, C1-20 straight or branched alkyl, diC1-3 straight or branched alkylamino C1-3 straight or branched alkyl, or C6-10 aryl, and B1 and B2 are linked to each other to form 5-10 membered heterocycloalkyl nonsubstituted or substituted with one or more benzyl groups containing one or more heteroatoms selected from the group consisting of N, O and S,
C1 is hydrogen, C1-20 straight or branched alkyl, or C1-20 straight or branched alkoxy,
D1 and D2 are independently hydrogen, hydroxy, C1-20 straight or branched alkyl saturated or containing one or more carbon≡carbon unsaturated bonds, C1-20 straight or branched alkyl nonsubstituted or substituted with one or more cyano groups, or C1-20 straight or branched alkylsulfonyl,
E1 is C1-20 straight or branched alkyl, or C6-10 aryl C1-5 straight or branched alkyl,
F1 is C1-20 straight or branched alkyl, or C6-10 aryl,
G1 is C1-20 straight or branched alkyl, or C6-10 aryl;
R4 is hydrogen, hydroxy, halogen, nitro, C1-20 straight or branched alkyl nonsubstituted or substituted with one or more ═S groups, C1-20 straight or branched alkylsulfanyl nonsubstituted or substituted with one or more oxo (═O) groups, C1-20 straight or branched alkylsulfonyl, 5-10 membered heterocycloalkyloxy nonsubstituted or substituted with one or more C1-5 straight or branched alkoxycarbonyl containing one or more heteroatoms selected from the group consisting of N, O and S, nonsubstituted or substituted 5-10 membered heteroaryl containing one or more heteroatoms selected from the group consisting of N, O and S, nonsubstituted or substituted C1-20 straight or branched alkoxy,
wherein, the substituted 5-10 membered heteroaryl can be substituted with one or more substituents selected from the group consisting of C1-3 straight or branched alkyl, C1-3 straight or branched alkoxy and C1-3 straight or branched alkoxy C1-3 straight or branched alkyl,
wherein, the substituted C1-20 straight or branched alkoxy can be substituted with one or more substituents selected from the group consisting of halogen, cyano, C1-3 straight or branched alkoxy, nonsubstituted or substituted 5-10 membered heterocycloalkyl containing one or more heteroatoms selected from the group consisting of N, O and S, and nonsubstituted or substituted C6-10 aryl,
wherein, the substituted 5-10 membered heterocycloalkyl and the substituted C6-10 aryl can be independently substituted with one or more substituents selected from the group consisting of cyano,
C1-5 straight or branched alkoxycarbonyl, and 5-8 membered heteroaryl nonsubstituted or substituted with one or more N groups,
A3 is hydrogen, or C1-20 straight or branched alkyl,
B3 and B4 are independently hydrogen, C1-20 straight or branched alkyl, diC1-3 straight or branched alkylamino C1-3 straight or branched alkyl, nonsubstituted or substituted C6-10 aryl, nonsubstituted or substituted C6-10 aryl C1-3 straight or branched alkyl, and B3 and B4 are linked to each other to form 5-10 membered heterocycloalkyl nonsubstituted or substituted with one or more benzyl groups containing one or more heteroatoms selected from the group consisting of N, O and S,
wherein, the substituted C6-10 aryl can be substituted with one or more substituents selected from the group consisting of amine, halogen, C1-5 straight or branched alkyl and C1-5 straight or branched alkoxy,
C3, C4 and C5 are independently hydrogen, amine, halogen, C1-20 straight or branched alkyl, or C1-20 straight or branched alkoxy,
D3 and D4 are independently hydrogen, hydroxy, C1-20 straight or branched alkyl saturated or containing one or more carbon≡carbon unsaturated bonds, C1-20 straight or branched alkyl nonsubstituted or substituted with one or more cyano groups, or C1-20 straight or branched alkylsulfonyl nonsubstituted or substituted with one or more halogens, and D3 and D4 are linked to each other to form 5-10 membered heteroaryl containing one or more heteroatoms selected from the group consisting of N, O and S, or 5-10 membered heterocycloalkyl fused with 5 membered heteroaryl nonsubstituted or substituted with one or more methyl groups or containing one S group and one or more heteroatoms selected from the group consisting of N, O and S,
E3 is C1-20 straight or branched alkyl, or C6-10 aryl C1-5 straight or branched alkyl,
F3 is C1-20 straight or branched alkyl, or C6-10 aryl,
G3 is C1-20 straight or branched alkyl, or C6-10 aryl,
H3 is C6-10 aryl, 5-10 membered heterocycloalkyl containing one or more heteroatoms selected from the group consisting of N, O and S, or 5-10 membered heteroaryl nonsubstituted or substituted with one or more methyl groups containing one or more heteroatoms selected from the group consisting of N, O and S,
I3 is diC1-3 straight or branched alkylamino;
R5 is hydrogen, halogen, C1-20 straight or branched alkyl nonsubstituted or substituted with one or more halogens, or C1-20 straight or branched alkoxy;
R6 is
B5 and B6 are independently hydrogen, C1-20 straight or branched alkyl, C6-10 aryl C1-3 straight or branched alkyl, or 5-10 membered heteroaryl C1-3 straight or branched alkyl containing one or more heteroatoms selected from the group consisting of N, O and S,
D5 and D6 are independently hydrogen, hydroxy, C1-20 straight or branched alkyl saturated or containing one or more carbon≡carbon unsaturated bonds, C1-20 straight or branched alkyl nonsubstituted or substituted with one or more cyano groups, or C1-20 straight or branched alkylsulfonyl nonsubstituted or substituted with one or more halogens,
E5 is C1-20 straight or branched alkyl saturated or containing one or more carbon≡carbon unsaturated bonds, C1-20 straight or branched alkoxy saturated or containing one or more carbon═carbon unsaturated bonds, C3-10 cycloalkyloxy, C3-10 cycloalkyl C1-3 straight or branched alkyl, C3-10 cycloalkyl, C6-10 aryloxy, C6-10 aryl C1-3 straight or branched alkoxy, C1-20 straight or branched alkylsulfanyl, nonsubstituted or substituted C6-10 aryl, diC1-3 straight or branched alkylamino, 5-10 membered heterocycloalkyl containing one or more heteroatoms selected from the group consisting of N, O and S, or nonsubstituted or substituted 5-10 membered heteroaryl containing one or more N groups,
wherein, the substituted C1-20 straight or branched alkyl can be substituted with one or more substituents selected from the group consisting of hydroxy, halogen, C1-3 straight or branched alkoxy, C1-3 straight or branched alkylcarbonyloxy, C1-3 straight or branched alkoxycarbonyl, hydroxycarbonyl, C6-10 aryl nonsubstituted or substituted with one or more hydroxyl groups, 5-10 membered heteroaryl containing one or more heteroatoms selected from the group consisting of N, O and S, and
T1 and T2 are independently hydrogen, C1-5 straight or branched alkyl, C1-5 straight or branched alkoxycarbonyl, C1-5 straight or branched alkylcarbonyl nonsubstituted or substituted with one or more halogens or hydroxyl groups, and T1 and T2 are linked to each other to form heterocycloalkyl nonsubstituted or substituted with one or more hydroxyl groups or C1-3 straight or branched alkyl groups containing one S group and one or more heteroatoms selected from the group consisting of N, O and S,
wherein, the substituted C6-10 aryl and the substituted 5-10 membered heteroaryl can be independently substituted with one or more substituents selected from the group consisting of halogen, nitro, C1-5 straight or branched alkyl and C1-5 straight or branched alkoxy,
F5 is C1-20 straight or branched alkyl, C3-10 cycloalkyl, or C6-10 aryl nonsubstituted or substituted with one or more halogens,
G5 is C1-20 straight or branched alkyl;
M is C1-20 straight or branched alkylene; and
X is —NH—.

### Claim 2 (depends on 1)

The compound represented by formula 1, the optical isomer thereof or the pharmaceutically acceptable salt thereof according to claim 1, wherein:
R1 is C1-10 straight or branched alkyl nonsubstituted or substituted with one or more halogens, or C6-10 aryl;
R2 is hydrogen, C1-10 straight or branched alkyl, or C1-10 straight or branched alkoxy;
R3 is hydrogen, nitro, halogen, nonsubstituted or substituted C1-10 straight or branched alkyl, nonsubstituted or substituted C1-10 straight or branched alkoxy, 5-10 membered heteroaryl nonsubstituted or substituted with one or more methyl groups containing one or more heteroatoms selected from the group consisting of N, O and S,
which forms 6 membered cycloalkyl containing one or more heteroatoms selected from the group consisting of S and O along with R4,
wherein, the substituted C1-10 straight or branched alkyl and the substituted C1-10 straight or branched alkoxy can be independently substituted with one or more substituents selected from the group consisting of halogen, C1-3 straight or branched alkoxy, 5-10 membered heterocycloalkyl containing one or more heteroatoms selected from the group consisting of N, O and S, and C6-10 aryl nonsubstituted or substituted with one or more nitro groups,
A1 is hydrogen, or C1-10 straight or branched alkyl,
B1 and B2 are independently hydrogen, C1-10 straight or branched alkyl, diC1-3 straight or branched alkylamino C1-3 straight or branched alkyl, or C6-10 aryl, and B1 and B2 are linked to each other to form 5-10 membered heterocycloalkyl nonsubstituted or substituted with one or more benzyl groups containing one or more heteroatoms selected from the group consisting of N, O and S,
C1 is hydrogen, C1-10 straight or branched alkyl, or C1-10 straight or branched alkoxy,
D1 and D2 are independently hydrogen, hydroxy, C1-10 straight or branched alkyl saturated or containing one or more carbon≡carbon unsaturated bonds, C1-10 straight or branched alkyl nonsubstituted or substituted with one or more cyano groups, or C1-10 straight or branched alkylsulfonyl,
E1 is C1-10 straight or branched alkyl, or C6-10 aryl C1-5 straight or branched alkyl,
F1 is C1-10 straight or branched alkyl, or C6-10 aryl,
G1 is C1-10 straight or branched alkyl, or C6-10 aryl;
R4 is hydrogen, hydroxy, halogen, nitro, C1-10 straight or branched alkyl nonsubstituted or substituted with one or more ═S groups, C1-10 straight or branched alkylsulfanyl nonsubstituted or substituted with one or more oxo (═O) groups, C1-10 straight or branched alkylsulfonyl, 5-10 membered heterocycloalkyloxy nonsubstituted or substituted with one or more C1-5 straight or branched alkoxycarbonyl containing one or more heteroatoms selected from the group consisting of N, O and S, nonsubstituted or substituted 5-10 membered heteroaryl containing one or more heteroatoms selected from the group consisting of N, O and S, nonsubstituted or substituted C1-10 straight or branched alkoxy,
wherein, the substituted 5-10 membered heteroaryl can be substituted with one or more substituents selected from the group consisting of C1-3 straight or branched alkyl, C1-3 straight or branched alkoxy and C1-3 straight or branched alkoxy C1-3 straight or branched alkyl,
wherein, the substituted C1-10 straight or branched alkoxy can be substituted with one or more substituents selected from the group consisting of halogen, cyano, C1-3 straight or branched alkoxy, nonsubstituted or substituted 5-10 membered heterocycloalkyl containing one or more heteroatoms selected from the group consisting of N, O and S, and nonsubstituted or substituted C6-10 aryl,
wherein, the substituted 5-10 membered heterocycloalkyl and the substituted C6-10 aryl can be independently substituted with one or more substituents selected from the group consisting of cyano,
C1-5 straight or branched alkoxycarbonyl, and 5-8 membered heteroaryl nonsubstituted or substituted with one or more N groups,
A3 is hydrogen, or C1-10 straight or branched alkyl,
B3 and B4 are independently hydrogen, C1-10 straight or branched alkyl, diC1-3 straight or branched alkylamino C1-3 straight or branched alkyl, nonsubstituted or substituted C6-10 aryl, nonsubstituted or substituted C6-10 aryl C1-3 straight or branched alkyl, and B3 and B4 are linked to each other to form 5-10 membered heterocycloalkyl nonsubstituted or substituted with one or more benzyl groups containing one or more heteroatoms selected from the group consisting of N, O and S,
wherein, the substituted C6-10 aryl can be substituted with one or more substituents selected from the group consisting of amine, halogen, C1-5 straight or branched alkyl and C1-5 straight or branched alkoxy,
C3, C4 and C5 are independently hydrogen, amine, halogen, C1-10 straight or branched alkyl, or C1-10 straight or branched alkoxy,
D3 and D4 are independently hydrogen, hydroxy, C1-10 straight or branched alkyl saturated or containing one or more carbon≡carbon unsaturated bonds, C1-10 straight or branched alkyl nonsubstituted or substituted with one or more cyano groups, or C1-10 straight or branched alkylsulfonyl nonsubstituted or substituted with one or more halogens, and D3 and D4 are linked to each other to form 5-10 membered heteroaryl containing one or more heteroatoms selected from the group consisting of N, O and S, or 5-10 membered heterocycloalkyl fused with 5 membered heteroaryl nonsubstituted or substituted with one or more methyl groups or containing one S group and one or more heteroatoms selected from the group consisting of N, O and S,
E3 is C1-10 straight or branched alkyl, or C6-10 aryl C1-5 straight or branched alkyl,
F3 is C1-10 straight or branched alkyl, or C6-10 aryl,
G3 is C1-10 straight or branched alkyl, or C6-10 aryl,
H3 is C6-10 aryl, 5-10 membered heterocycloalkyl containing one or more heteroatoms selected from the group consisting of N, O and S, or 5-10 membered heteroaryl nonsubstituted or substituted with one or more methyl groups containing one or more heteroatoms selected from the group consisting of N, O and S,
I3 is diC1-3 straight or branched alkylamino;
R5 is hydrogen, halogen, C1-10 straight or branched alkyl nonsubstituted or substituted with one or more halogens, or C1-10 straight or branched alkoxy;
R6 is
B5 and B6 are independently hydrogen, C1-10 straight or branched alkyl, C6-10 aryl C1-3 straight or branched alkyl, or 5-10 membered heteroaryl C1-3 straight or branched alkyl containing one or more heteroatoms selected from the group consisting of N, O and S,
D5 and D6 are independently hydrogen, hydroxy, C1-10 straight or branched alkyl saturated or containing one or more carbon≡carbon unsaturated bonds, C1-10 straight or branched alkyl nonsubstituted or substituted with one or more cyano groups, or C1-10 straight or branched alkylsulfonyl nonsubstituted or substituted with one or more halogens,
E5 is C1-10 straight or branched alkyl saturated or containing one or more carbon═carbon unsaturated bonds, C1-10 straight or branched alkoxy saturated or containing one or more carbon═carbon unsaturated bonds, C3-10 cycloalkyloxy, C3-10 cycloalkyl C1-3 straight or branched alkyl, C3-10 cycloalkyl, C6-10 aryloxy, C6-10 aryl C1-3 straight or branched alkoxy, C1-10 straight or branched alkylsulfanyl, nonsubstituted or substituted C6-10 aryl, diC1-3 straight or branched alkylamino, 5-10 membered heterocycloalkyl containing one or more heteroatoms selected from the group consisting of N, O and S, or nonsubstituted or substituted 5-10 membered heteroaryl containing one or more N groups,
wherein, the substituted C1-10 straight or branched alkyl can be substituted with one or more substituents selected from the group consisting of hydroxy, halogen, C1-3 straight or branched alkoxy, C1-3 straight or branched alkylcarbonyloxy, C1-3 straight or branched alkoxycarbonyl, hydroxycarbonyl, C6-10 aryl nonsubstituted or substituted with one or more hydroxyl groups, 5-10 membered heteroaryl containing one or more heteroatoms selected from the group consisting of N, O and S, and
T1 and T2 are independently hydrogen, C1-5 straight or branched alkyl, C1-5 straight or branched alkoxycarbonyl, C1-5 straight or branched alkylcarbonyl nonsubstituted or substituted with one or more halogens or hydroxyl groups, and T1 and T2 are linked to each other to form heterocycloalkyl nonsubstituted or substituted with one or more hydroxyl groups or C1-3 straight or branched alkyl groups containing one S group and one or more heteroatoms selected from the group consisting of N, O and S,
wherein, the substituted C6-10 aryl and the substituted 5-10 membered heteroaryl can be independently substituted with one or more substituents selected from the group consisting of halogen, nitro, C1-5 straight or branched alkyl and C1-5 straight or branched alkoxy,
F5 is C1-10 straight or branched alkyl, C3-10 cycloalkyl, or C6-10 aryl nonsubstituted or substituted with one or more halogens,
G5 is C1-10 straight or branched alkyl,
M is C1-10 straight or branched alkylene; and
X is —NH—.

### Claim 3 (depends on 1)

The compound represented by formula 1, the optical isomer thereof or the pharmaceutically acceptable salt thereof according to claim 1, wherein:
R1 is —CH3, —CH2CH3, —CF3,
R2 is —H, —CH3, or —OCH3;
R3 is —H, —Cl, —F, —CH3, —CF3, —OCH3, —OCF3, —NO2, —NH2,
which forms
along with R4;
R4 is —H, —OH, —Cl, —F, —CH3, —OCH3, —SCH3, —OCF3, —NO2, —NH2,
R5 is —H, —Cl, —CH3, —CF3, or —OCH3;
R6 is —NH2,
M is C3-4 straight or branched alkylene; and
X is —NH—.

### Claim 4 (depends on 1)

The compound represented by formula 1, the optical isomer thereof or the pharmaceutically acceptable salt thereof according to claim 1, wherein the compound represented by formula 1 is selected from the group consisting of the following compounds:
(1) [4-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(2) N1-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine dihydrochloride;
(3) 2,2-dimethyl-N-[4-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-propionamide;
(4) [4-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isopropylester;
(5) [4-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-acetamide;
(6) [4-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-isobutyramide;
(7) 3-methyl-N-[4-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-butyramide;
(8) 3,3-dimethyl-N-[4-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-butyramide;
(9) 2-(R)-hydroxy-N-[4-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(10) 2-(S)-hydroxy-N-[4-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(11) N-[4-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(12) 2-chloro-N-[4-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(13) 2,6-dimethyl-N-[4-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(14) 4-chloro-N-[4-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(15) 3-chloro-N-[4-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(16) 3,4-dichloro-N-[4-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(17) 2,3-dichloro-N-[4-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(18) 3,5-dichloro-N-[4-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(19) 2,6-dichloro-N-[4-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-nicotinamide;
(20) 6-chloro-N-[4-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-nicotinamide;
(21) 2-chloro-6-methyl-N-[4-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-nicotinamide;
(22) 1-tert-butyl-3-[4-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-urea;
(23) 1-(4-fluoro-phenyl)-3-[4-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-urea;
(24) 1-(3-fluoro-phenyl)-3-[4-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-urea;
(25) [4-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid benzylester;
(26) [4-(7,8-dichloro-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(27) N1-(7,8-dichloro-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)butane-1,4-diamine ditrifluoroacetic acid;
(28) N-[4-(7,8-dichloro-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2,2-dimethyl-propionamide;
(29) N-[4-(7,8-dichloro-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-isobutyramide;
(30) N-[4-(7,8-dichloro-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(31) N-[4-(7,8-dichloro-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(32) 2-chloro-N-[4-(7,8-dichloro-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(33) 6-chloro-N-[4-(7,8-dichloro-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-nicotinamide;
(34) [4-(1,7,8-trimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(35) [4-(7,8-difluoro-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(36) N1-(7,8-difluoro-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine ditrifluoroacetic acid;
(37) N-[4-(7,8-difluoro-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(38) N-[4-(7,8-difluoro-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2-(R)-hydroxy-3-methyl-butyramide;
(39) N-[4-(7,8-difluoro-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2-(S)-hydroxy-3-methyl-butyramide;
(40) [4-(1,8-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(41) [4-(1,8-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butane]-1,4-diamine dihydrochloride;
(42) N-[4-(1,8-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2,2-dimethyl-propionamide;
(43) N-[4-(1,8-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-isobutyramide;
(44) 1-tert-butyl-3-[4-(1,8-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-urea;
(45) N-[4-(1,8-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(46) 1-[4-(1,8-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-phenyl-urea;
(47) [4-(8-fluoro-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(48) [4-(8-fluoro-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-1,4-diamine dihydrochloride;
(49) N-[4-(8-fluoro-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2,2-dimethyl-propionamide;
(50) [4-(8-fluoro-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-isobutyramide;
(51) N-[4-(8-fluoro-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(52) 1-tert-butyl-3-[4-(8-fluoro-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-urea;
(53) 1-[4-(8-fluoro-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-phenyl-urea;
(54) [4-(8-chloro-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(55) N1-(8-chloro-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)butane-1,4-diamine hydrochloride;
(56) N-[4-(8-chloro-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(57) [4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(58) N1-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine ditrifluoroacetic acid;
(59) N-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2,2-dimethyl-propionamide;
(60) [4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isopropylester;
(61) [4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid ethylester;
(62) [4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isobutylester;
(63) [4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-sec-butylester;
(64) [4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid propylester;
(65) [4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid allylester;
(66) [4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid cyclopentylester;
(67) [4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid phenylester;
(68) [4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid benzylester;
(69) N-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-acetamide;
(70) N-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-isobutyramide;
(71) 3-methyl-buten-2-oic acid-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-amide;
(72) butene-2-oic acid-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-amide;
(73) 3-methyl-pentanoic acid-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-amide;
(74) N-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(75) N-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3,3-dimethyl-butyramide;
(76) cyclopropanecarboxylic acid-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-amide;
(77) N-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2-methyl-butyramide;
(78) N-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2-ethyl-butyramide;
(79) 4-methyl-pentanoic acid-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-amide;
(80) N-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2-methoxy-acetamide;
(81) 3-cyclopentyl-N-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-propionamide;
(82) N-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2-(R)-hydroxy-3-methyl-butyramide;
(83) N-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2-(S)-hydroxy-3-methyl-butyramide;
(84) N-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2-thiophene-2-yl-acetamide;
(85) N-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2-furan-2-yl-acetamide;
(86) N-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2-phenyl-acetamide;
(87) acetic acid-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamoyl]-methylester;
(88) 1-tert-butyl-3-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-urea;
(89) 1-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-ethyl-urea;
(90) 1-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-3-isopropyl-urea;
(91) 3-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-1,1-dimethyl-urea;
(92) morpholine-4-carboxylic acid-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-amide;
(93) 1-cyclohexyl-3-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-urea;
(94) 1-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-phenyl-urea;
(95) N-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(96) 4-tert-butyl-N-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(97) N-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2-methoxy-benzamide;
(98) N-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-4-fluoro-benzamide;
(99) 2-chloro-N-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(100) 4-chloro-N-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(101) N-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-4-nitro-benzamide;
(102) 2,3-dichloro-N-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(103) N-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-isonicotinamide;
(104) N-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-nicotinamide;
(105) pyridine-2-carboxylic acid-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-amide;
(106) N-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2-fluoro-benzamide;
(107) 6-chloro-N-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-nicotinamide;
(108) 2-chloro-N-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-6-methyl-nicotinamide;
(109) N-[4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-methanesulfonamide;
(110) [4-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-thiocarbamic acid-S-isopropylester;
(111) [4-(8-fluoro-1-methyl-6-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(112) N1-(8-fluoro-1-methyl-6-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine dihydrochloride;
(113) N-[4-(8-fluoro-1-methyl-6-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2,2-dimethyl-propionamide;
(114) [4-(8-fluoro-1-methyl-6-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isopropylester;
(115) [4-(8-fluoro-1-methyl-6-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isobutylester;
(116) N-[4-(8-fluoro-1-methyl-6-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3,3-dimethyl-butyramide;
(117) [4-(6-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(118) N1-(6-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine dihydrochloride;
(119) N-[4-(6-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2,2-dimethyl-propionamide;
(120) N-[4-(6-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isobutylester;
(121) [4-(8-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(122) N1-(8-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine ditrifluoroacetic acid;
(123) N-[4-(8-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2,2-dimethyl-propionamide;
(124) [4-(8-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3,3-dimethyl-butyramide;
(125) 2-(R)-hydroxy-N-[4-(8-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(126) 2-(S)-hydroxy-N-[4-(8-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(127) N-[4-(8-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(128) 2-chloro-N-[4-(8-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(129) 2-chloro-N-[4-(8-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-6-methyl-nicotinamide;
(130) {4-[6-methoxy-1,7-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid-tert-butylester;
(131) N1-(6-methoxy-1,7-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine ditrifluoroacetic acid;
(132) [4-(6-methoxy-1,7-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2,2-dimethyl-propionamide;
(133) [4-(6-methoxy-1,7-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isopropylester;
(134) [4-(6-methoxy-1,7-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isobutylester;
(135) N-[4-(6-methoxy-1,7-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(136) 2-(R)-hydroxy-N-[4-(6-methoxy-1,7-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(137) 2-(S)-hydroxy-N-[4-(6-methoxy-1,7-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(138) N-[4-(6-methoxy-1,7-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(139) 2-fluoro-N-[4-(6-methoxy-1,7-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(140) 2-chloro-N-[4-(6-methoxy-1,7-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(141) 2-chloro-N-[4-(6-methoxy-1,7-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-6-methyl-nicotinamide;
(142) [4-(6-methoxy-1-methyl-8-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(143) N1-(6-methoxy-1-methyl-8-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine ditrifluoroacetic acid;
(144) [4-(6-methoxy-1-methyl-8-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isopropylester;
(145) N-[4-(6-methoxy-1-methyl-8-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(146) [4-(8-methoxy-1,7-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(147) N1-(8-methoxy-1,7-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine ditrifluoroacetic acid;
(148) N-[4-(8-methoxy-1,7-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2,2-dimethyl-propionamide;
(149) [4-(8-methoxy-1,7-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isopropylester;
(150) [4-(8-methoxy-1,7-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isobutylester;
(151) N-[4-(8-methoxy-1,7-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(152) 2-(R)-hydroxy-N-[4-(8-methoxy-1,7-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(153) 2-(S)-hydroxy-N-[4-(8-methoxy-1,7-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(154) N-[4-(8-methoxy-1,7-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(155) 2-fluoro-N-[4-(8-methoxy-1,7-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(156) 2-chloro-N-[4-(8-methoxy-1,7-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(157) 2-chloro-N-[4-(8-methoxy-1,7-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-6-methyl-nicotinamide;
(158) [4-(8-methoxy-1,6-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(159) N1-(8-methoxy-1,6-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine difluoroacetic acid;
(160) N-[4-(8-methoxy-1,6-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(161) [4-(8-methoxy-1,6-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isopropylester;
(162) {4-[7,8-bis-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid-tert-butylester;
(163) N1-[7,8-bis-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl]-butane-1,4-diamine ditrifluoroacetic acid;
(164) N-{4-[7,8-bis-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-2,2-dimethyl-propionamide;
(165) {4-[7,8-bis-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid isopropylester;
(166) N-{4-[7,8-bis-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(167) N-{4-[7,8-bis-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3,3-dimethyl-butyramide;
(168) {4-[7,8-bis-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid isobutylester;
(169) 1-{4-[7,8-bis-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-tert-butyl-urea;
(170) N-{4-[7,8-bis-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-benzamide;
(171) N-{4-[7,8-bis-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-2-chloro-benzamide;
(172) N-{4-[7,8-bis-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-2-chloro-6-methyl-nicotinamide;
(173) [4-(7,8-diethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl-carbamic acid-tert-butylester;
(174) N1-(7,8-diethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine ditrifluoroacetic acid;
(175) [4-(7,8-diethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isopropylester;
(176) [4-(7,8-diethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isobutylester;
(177) N-[4-(7,8-diethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl-3-methyl-butyramide;
(178) [4-(1-methyl-8,9-dihydro-7,10-dioxa-2,3,5,11b-tetraaza-cyclopenta[a]anthracene-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(179) N1-(1-methyl-8,9-dihydro-7,10-dioxa-2,3,5,11b-tetraaza-cyclopenta[a]anthracene-4-yl)-butane-1,4-diamine ditrifluoroacetic acid;
(180) 2,2-dimethyl-N-[4-(1-methyl-8,9-dihydro-7,10-dioxa-2,3,5,11b-tetraaza-cyclopenta[a]anthracene-4-ylamino)-butyl]-propionamide;
(181) 3-methyl-N-[4-(1-methyl-8,9-dihydro-7,10-dioxa-2,3,5,11b-tetraaza-cyclopenta[a]anthracene-4-ylamino)-butyl]-butyramide;
(182) 2-(R)-hydroxy-3-methyl-N-[4-(1-methyl-8,9-dihydro-7,10-dioxa-2,3,5,11b-tetraaza-cyclopenta[a]anthracene-4-ylamino)-butyl]-butyramide;
(183) 2-(S)-hydroxy-3-methyl-N-[4-(1-methyl-8,9-dihydro-7,10-dioxa-2,3,5,11b-tetraaza-cyclopenta[a]anthracene-4-ylamino)-butyl]-butyramide;
(184) acetic acid-[4-(1-methyl-8,9-dihydro-7,10-dioxa-2,3,5,11b-tetraaza-cyclopenta[a]anthracene-4-ylamino)-butyl]-carbamoyl]-methylester;
(185) N-[4-(1-methyl-8,9-dihydro-7,10-dioxa-2,3,5,11b-tetraaza-cyclopenta[a]anthracene-4-ylamino)-butyl]-2-thiophene-2-yl-acetamide;
(186) N-[4-(1-methyl-8,9-dihydro-7,10-dioxa-2,3,5,11b-tetraaza-cyclopenta[a]anthracene-4-ylamino)-butyl]-benzamide;
(187) 2-chloro-N-[4-(1-methyl-8,9-dihydro-7,10-dioxa-2,3,5,11b-tetraaza-cyclopenta[a]anthracene-4-ylamino)-butyl]-benzamide;
(188) [4-(1-methyl-8,9-dihydro-7,10-dioxa-2,3,5,11b-tetraaza-cyclopenta[a]anthracene-4-ylamino)-butyl]-carbamic acid isopropylester;
(189) [4-(1-methyl-8,9-dihydro-7,10-dioxa-2,3,5,11b-tetraaza-cyclopenta[a]anthracene-4-ylamino)-butyl]-carbamic acid isobutylester;
(190) [4-(1-methyl-8,9-dihydro-7,10-dioxa-2,3,5,11b-tetraaza-cyclopenta[a]anthracene-4-ylamino)-butyl]-carbamic acid cyclopentylester;
(191) [4-(1-methyl-8,9-dihydro-7,10-dioxa-2,3,5,11b-tetraaza-cyclopenta[a]anthracene-4-ylamino)-butyl]-carbamic acid phenylester;
(192) 1-isopropyl-3-[4-(1-methyl-8,9-dihydro-7,10-dioxa-2,3,5,11b-tetraaza-cyclopenta[a]anthracene-4-ylamino)-butyl]-urea;
(193) [4-(6,7,8-trimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(194) N1-(6,7,8-trimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine ditrifluoroacetic acid;
(195) 3-methyl-N-[4-(6,7,8-trimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-butyramide;
(196) 3-methyl-pentanoic acid-[4-(6,7,8-trimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-amide;
(197) 4-(4-tert-butoxycarbamoylamino-butylamino)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-7-carboxylic acid methylester;
(198) 4-(4-amino-butylamino)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-7-carboxylic acid methylester ditrifluoroacetic acid;
(199) 1-methyl-4-[4-(3-methyl-butyrylamino)-butylamino]-[1,2,4]triazolo[4,3-a]quinoxaline-7-carboxylic acid methylester;
(200) 4-[(4-tert-butoxycarbamoylamino)-butylamino]-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-7-carboxylic acid;
(201) 1-methyl-4-[4-(3-methyl-butyrylamino)-butylamino]-[1,2,4]triazolo[4,3-a]quinoxaline-7-carboxylic acid;
(202) [4-(7-isopropylcarbamoyl-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(203) [4-(7-tert-butylcarbamoyl-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(204) 4-(4-isobutyramido-butylamino)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-7-carboxylic acid isopropylamide;
(205) 4-(4-benzoylamino-butylamino)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-7-carboxylic acid isopropylamide;
(206) {4-[7-(2-dimethylamino-ethylcarbamoyl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid-tert-butylester;
(207) 4-(4-benzoylamino-butylamino)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-7-carboxylic acid-(2-dimethylamino-ethyl)-amide;
(208) N-{4-[7-(4-benzyl-piperazine-1-carbonyl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-benzamide;
(209) N-{4-[1-methyl-7-(piperazine-1-carbonyl)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-benzamide;
(210) [4-(7-benzylcarbamoyl-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(211) {4-[7-(4-chloro-benzylcarbamoyl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid-tert-butylester;
(212) [4-(1-methyl-7-phenylcarbamoyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(213) {4-[7-(2-amino-phenylcarbamoyl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid-tert-butylester;
(214) {4-[7-(2-amino-4-methyl-phenylcarbamoyl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid-tert-butylester;
(215) 1-methyl-4-[4-(3-methyl-butyrylamino)-butylamino]-[1,2,4]triazolo[4,3-a]quinoxaline-7-carboxylic acid-(2-amino-phenyl)-amide;
(216) 1-methyl-4-[4-(3-methyl-butyrylamino)-butylamino]-[1,2,4]triazolo[4,3-a]quinoxaline-7-carboxylic acid-(2-amino-4-methyl-phenyl)-amide;
(217) 1-methyl-4-[4-(3-methyl-butyrylamino)-butylamino]-[1,2,4]triazolo[4,3-a]quinoxaline-7-carboxylic acid-(2-amino-4,5-dimethoxy-phenyl)-amide;
(218) {4-[7-(1H-benzoimidazole-2-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid-tert-butylester;
(219) {4-[1-methyl-7-(5-methyl-1H-benzoimidazole-2-yl)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid-tert-butylester;
(220) {4-[1-methyl-7-(1-methyl-1H-benzoimidazole-2-yl)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid-tert-butylester;
(221) N1-[1-methyl-7-(1-methyl-1H-benzoimidazole-2-yl)-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl]-butane-1,4-diamine ditrifluoroacetic acid;
(222) 3-methyl-N-{4-[1-methyl-7-(1-methyl-1H-benzoimidazole-2-yl)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-butyramide;
(223) 3-methyl-N-{4-[1-methyl-7-(5-methyl-1H-benzoimidazole-2-yl)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-butyramide;
(224) N-{4-[7-(1H-benzoimidazole-2-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(225) N-{4-[7-(1H-benzoimidazole-2-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-2-(S)-hydroxy-3-methyl-butyramide;
(226) N-{4-[7-(1H-benzoimidazole-2-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-2-(R)-hydroxy-3-methyl-butyramide;
(227) N-{4-[7-(5,6-dimethoxy-1H-benzoimidazole-2-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(228) {4-[1-methyl-7-(1-methyl-1H-benzoimidazole-2-yl)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid propylester;
(229) {4-[1-methyl-7-(1-methyl-1H-benzoimidazole-2-yl)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid cyclopentylester;
(230) 2,2-dimethyl-N-{4-[1-methyl-7-(1-methyl-1H-benzoimidazole-2-yl)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-propionamide;
(231) acetic acid-1-{4-[7-(1-methyl-1H-benzoimidazole-2-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butylcarbamoyl}-1-methyl-ethylester;
(232) 2-hydroxy-N-{4-(7-(1-methyl-1H-benzoimidazole-2-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl}-2-methyl-propionamide;
(233) 2,2-difluoro-N-{4-[1-methyl-7-(1-methyl-1H-benzoimidazole-2-yl)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-butyramide;
(234) 2-(S)-hydroxy-3-methyl-N-{4-[1-methyl-7-(1-methyl-1H-benzoimidazole-2-yl)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-butyramide;
(235) 2-(R)-hydroxy-3-methyl-N-{4-[1-methyl-7-(1-methyl-1H-benzimidazole-2-yl)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-butyramide;
(236) 4-methyl-pentanoic acid-{4-[1-methyl-7-(1-methyl-1H-benzoimidazole-2-yl)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-amide;
(237) 2-methoxy-N-{4-[1-methyl-7-(1-methyl-1H-benzoimidazole-2-yl)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-benzamide;
(238) 1-isopropyl-3-{4-[1-methyl-7-(1-methyl-1H-benzoimidazole-2-yl)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-urea;
(239) 1-cyclohexyl-3-{4-[1-methyl-7-(1-methyl-1H-benzoimidazole-2-yl)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-urea;
(240) 3-methyl-N-{4-[1-methyl-7-(1-propyl-1H-benzoimidazole-2-yl)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-butyramide;
(241) N-(4-{7-[1-(2-methoxy-ethyl)-1H-benzoimidazole-2-yl]-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino}-butyl)-3-methyl-butyramide;
(242) [4-(1-methyl-7-nitro-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(243) [4-(7-amino-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(244) 3-methyl-N-[4-(1-methyl-8-nitro-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-butyramide;
(245) N-[4-(7-amino-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(246) [4-(7-isobutyramido-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(247) N-[4-(7-isobutyramido-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2,2-dimethyl-propionamide;
(248) N-[4-(7-isobutyramido-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(249) [4-(7-acetylamino-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(250) N-[4-(7-acetylamino-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2,2-dimethyl-propionamide;
(251) N-[4-(7-acetylamino-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(252) 3-methyl-N-[4-(1-methyl-7-methylamino-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-butyramide;
(253) 3-methyl-N-[4-(1-methyl-7-propylamino-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-butyramide;
(254) N-{4-[7-(3-cyano-propylamino)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(255) N-{4-[7-(3-isopropyl-ureido)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(256) N-{4-[7-(3-isopropyl-thioureido)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(257) N-[4-(7-methanesulfonylamino-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(258) 3-methyl-N-{4-[1-methyl-7-(2,2,2-trifluoro-ethanesulfonylamino)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-butyramide;
(259) 3-methyl-N-{4-[1-methyl-7-(propane-2-sulfonylamino)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-butyramide;
(260) [4-(7-benzoyl-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(261) {4-[7-(4-chloro-benzoyl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid-tert-butylester;
(262) {4-[7-(4-methoxy-benzoyl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid-tert-butylester;
(263) [4-(1-methyl-8-trifluoromethoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(264) N1-(1-methyl-8-trifluoromethoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine ditrifluoroacetic acid;
(265) 2,2-dimethyl-N-[4-(1-methyl-8-trifluoromethoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-propionamide;
(266) 3,3-dimethyl-N-[4-(1-methyl-8-trifluoromethoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-butyramide;
(267) N-[4-(1-methyl-8-trifluoromethoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(268) 2-chloro-N-[4-(1-methyl-8-trifluoromethoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(269) [4-(1-methyl-7-trifluoromethoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(270) N1-(1-methyl-7-trifluoromethoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine ditrifluoroacetic acid;
(271) 2,2-dimethyl-N-[4-(1-methyl-7-trifluoromethoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-propionamide;
(272) 3,3-dimethyl-N-[4-(1-methyl-7-trifluoromethoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-butyramide;
(273) N-[4-(1-methyl-7-trifluoromethoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(274) 2-chloro-N-[4-(1-methyl-7-trifluoromethoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(275) [4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(276) N1-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine ditrifluoroacetic acid;
(277) N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2,2-dimethyl-propionamide;
(278) [4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isopropylester;
(279) [4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isobutylester;
(280) [4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-sec-butylester;
(281) N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-isobutyramide;
(282) cyclopropanecarboxylic acid-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-amide;
(283) butene-2-oic acid-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-amide;
(284) 3-methyl-butene-2-oic acid-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-amide;
(285) N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(286) 2-(S)-fluoro-N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(287) N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3,3-dimethyl-butyramide;
(288) 4-methyl-pentanoic acid-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-amide;
(289) 3-methyl-pentanoic acid-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-amide;
(290) 2-ethyl-N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-butyramide;
(291) N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2-methyl-butyramide;
(292) 2,2,3,3,4,4,4-heptafluoro-N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-butyramide;
(293) 3,3,3-trifluoro-N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2,2-dimethyl-propaneamide;
(294) 2,2-difluoro-N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-butyramide;
(295) 2-(R)-hydroxy-N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-propaneamide;
(296) acetic acid-1-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butylcarbamoyl]-1-methyl-ethylester;
(297) 2-hydroxy-N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2-methyl-propionamide;
(298) 2-(R)-hydroxy-N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(299) 2-(S)-hydroxy-N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(300) 2-(R)-methoxy-N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(301) 2-(S)-methoxy-N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(302) 2-(S)-bromo-N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(303) acetic acid-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butylcarbamoyl]-methylester;
(304) 2-hydroxy-N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-acetamide;
(305) N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-malonamic acid ethylester;
(306) N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-malonamic acid;
(307) N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2-thiophene-2-yl-acetamide;
(308) 2-furan-2-yl-N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-acetamide;
(309) 3-cyclopentyl-N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-propionamide;
(310) {1-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butylcarbamoyl]-2-methyl-propyl}-carbamic acid-tert-butylester;
(311) 2-amino-N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(312) 2-(R)-dimethylamino-N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(313) 2-(S)-dimethylamino-N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(314) N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-2-(S)-morpholine-4-yl-butyramide;
(315) 2-(S)-(3-hydroxy-pyrrolidine-1-yl)-N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(316) 2-(S)-(4-hydroxy-piperidine-1-yl)-N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(317) 2-(S)-[4-(2-hydroxy-ethyl)-piperidine-1-yl]-N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(318) (S)-{1-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butylcarbamoyl]-2-methyl-propyl}-carbamic acid isobutylester;
(319) (S)-{1-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butylcarbamoyl]-2-methyl-propyl}-carbamic acid propylester;
(320) (S)-{1-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butylcarbamoyl]-2-methyl-propyl}-carbamic acid isopropylester;
(321) (S)-2-(S)-fluoro-N-{1-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl carbamoyl]-2-methyl-propyl}-3-methyl-butyramide;
(322) (S)—N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-2-(3-methyl-butyrylamino)-butyramide;
(323) (S)-2-(2,2-dimethyl-propionylamino)-N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(324) 2-(S)-(2(S)-hydroxy-propionylamino)-N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(325) {2-(S)-(4-hydroxy-phenyl)-1-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butylcarbamoyl]-ethyl}-carbamic acid-tert-butylester;
(326) 2-(S)-amino-3-(4-hydroxy-phenyl)-N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-propionamide;
(327) 2-(S)-methanesulfonylamino-N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(328) 2-fluoro-N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(329) N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2-phenyl-acetamide;
(330) 1-isopropyl-3-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-urea;
(331) 1-tert-butyl-3-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-urea;
(332) [4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid cyclopentylester;
(333) [4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid phenylester;
(334) 3-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-1,1-dimethyl-urea;
(335) 1-cyclohexyl-3-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-urea;
(336) [4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-thiocarbamic acid-S-isopropylester;
(337) 1-isopropyl-3-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-thiourea;
(338) N-[4-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-methanesulfonamide;
(339) N-{4-[7-methoxy-1-methyl-8-(4-nitro-benzyl)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(340) N-[4-(7-hydroxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(341) N-{4-[7-(4-cyano-benzyloxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(342) N-{4-[7-(3-cyano-propoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(343) 3-methyl-N-{4-[1-methyl-7-(tetrahydro-pyran-2-ylmethoxy)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-butyramide;
(344) 3-methyl-N-{4-[1-methyl-7-(tetrahydro-pyran-4-yloxy)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-butyramide;
(345) 4-{1-methyl-4-[4-(3-methyl-butylamino)-butylamino]-[1,2,4]triazolo[4,3-a]quinoxaline-7-yloxy}-piperidine-1-carboxylic acid-tert-butylester;
(346) N-[4-(7-benzyloxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(347) N-(4-{7-[4-(N-hydroxycarbamimidoyl)-benzoyl]-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino}-butyl)-3-methyl-butyramide;
(348) 3-methyl-N-(4-{1-methyl-7-[4-(2H-tetrazol-5-yl)-benzyloxy]-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino}-butyl)-butyramide;
(349) 3-methyl-N-(4-{1-methyl-7-[4-(2-methyl-2H-tetrazolo-5-yl)-benzyloxy]-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino}-butyl)-butyramide;
(350) benzoic acid-1-methyl-4-[4-(3-methyl-butylamino)-butylamino]-[1,2,4]triazolo[4,3-a]quinoxaline-7-yl-ester;
(351) morpholine-4-carboxylic acid-1-methyl-4-[4-(3-methyl-butylamino)-butylamino]-[1,2,4]triazolo[4,3-a]quinoxaline-7-yl-ester;
(352) 3-methyl-thiophene-2-carboxylic acid-1-methyl-4-[4-(3-methyl-butylamino)-butylamino]-[1,2,4]triazolo[4,3-a]quinoxaline-7-yl-ester;
(353) dimethyl-thiocarbamic acid-O-{1-methyl-4-[4-(3-methyl-butylamino)-butylamino]-[1,2,4]triazolo[4,3-a]quinoxaline-7-yl}-ester;
(354) [4-(1-methyl-7-methylsulfanyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(355) N1-(1-methyl-(7-methylsulfanyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine ditrifluoroacetic acid;
(356) 3-methyl-N-[4-(1-methyl-7-methylsulfanyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-butyramide;
(357) 2-(S)-fluoro-3-methyl-N-[4-(1-methyl-7-methylsulfanyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-butyramide;
(358) 2-(S)-hydroxy-3-methyl-N-[4-(1-methyl-7-methylsulfanyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-butyramide;
(359) N-[4-(7-methanesulfinyl-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(360) N-[4-(7-methanesulfonyl-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(361) [4-(7-fluoro-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(362) 4-(7-chloro-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-carbamic acid-tert-butylester;
(363) {4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid-tert-butylester;
(364) N1-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl]-butane-1,4-diamine ditrifluoroacetic acid;
(365) N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(366) {4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid isopropylester;
(367) {4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid propylester;
(368) {4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid-sec-butylester;
(369) {4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid isobutylester;
(370) {4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid allylester;
(371) {4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid cyclopentylester;
(372) {4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid phenylester;
(373) {4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid benzylester;
(374) {4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-acetamide;
(375) {4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-2,2-dimethyl-propionamide;
(376) {4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-isobutyramide;
(377) cyclopropanecarboxylic acid-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-amide;
(378) 3-methyl-butene-2-oic acid-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-amide;
(379) butene-2-oic acid-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-amide;
(380) N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-2-methyl-butyramide;
(381) 2-ethyl-N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-butyramide;
(382) N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3,3-dimethyl-butyramide;
(383) 4-methyl-pentanoic acid-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-amide;
(384) acetic acid-1-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butylcarbamoyl}-1-methyl-ethylester;
(385) 2-hydroxy-N-{4-(7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl}-2-methyl-propionamide;
(386) acetic acid-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butylcarbamoyl}-methylester;
(387) 2-hydroxy-N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-acetamide;
(388) 2-(R)-hydroxy-N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(389) 2-(S)-hydroxy-N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(390) 2-(R)-methoxy-N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(391) 2,2-difluoro-N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-butyramide;
(392) 3,3,3-trifluoro-N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-2,2-dimethyl-propionamide;
(393) 3-cyclopentyl-N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-propionamide;
(394) N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-malonamic acid ethylester;
(395) N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-malonamic acid;
(396) (1-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butylcarbamoyl}-2-methyl-propyl)-carbamic acid-tert-butylester;
(397) 2-amino-N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(398) (S)-(1-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butylcarbamoyl}-2-methyl-propyl)-carbamic acid isobutylester;
(399) (S)-(1-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butylcarbamoyl}-2-methyl-propyl)-carbamic acid propylester;
(400) (S)-(1-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butylcarbamoyl}-2-methyl-propyl)-carbamic acid isopropylester;
(401) (S)—N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-2-(3-methyl-butyrylamino)-butyramide;
(402) (S)-2-(2,2-dimethyl-propionylamino)-N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(403) 2-(S,R)-hydroxy-N-(1-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butylcarbamoyl}-2-methyl-propyl)-3-methyl-butyramide;
(404) 2-(S,S)-hydroxy-N-(1-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butylcarbamoyl}-2-methyl-propyl)-3-methyl-butyramide;
(405) 2-(S)-methanesulfonylamino-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(406) N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-2-thiophene-2-yl-acetamide;
(407) 2-furan-2-yl-N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-acetamide;
(408) N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-benzamide;
(409) 2-fluoro-N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-benzamide;
(410) 3-fluoro-N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-benzamide;
(411) 2-chloro-N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-benzamide;
(412) 2-chloro-N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-benzamide;
(413) 2,3-dichloro-N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-benzamide;
(414) 2-methoxy-N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-benzamide;
(415) N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-4-nitro-butyramide;
(416) pyridine-2-carboxylic acid-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-amide;
(417) N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-nicotinamide;
(418) N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-isonicotinamide;
(419) 6-chloro-N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-nicotinamide;
(420) N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-2-phenyl-acetamide;
(421) 3-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-1,1-dimethyl-urea;
(422) 1-isopropyl-3-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-urea;
(423) 1-ethyl-3-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-urea;
(424) 1-tert-butyl-3-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-urea;
(425) morpholine-4-carboxylic acid-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-amide;
(426) 1-cyclohexyl-3-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-urea;
(427) 3-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-1-phenyl-urea;
(428) {4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-thiocarbamic acid-S-isopropylester;
(429) N-{4-[7-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-methanesulfonamide;
(430) {4-[1-methyl-7-(2-morpholine-4-yl-ethoxy)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid-tert-butylester;
(431) N1-{4-[1-methyl-7-(2-morpholine-4-yl-ethoxy)-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl]-butane-1,4-diamine trifluoroacetic acid;
(432) 3-methyl-N-{4-[1-methyl-7-(2-morpholine-4-yl-ethoxy)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-butyramide;
(433) 2,2-dimethyl-N-{4-[1-methyl-7-(2-morpholine-4-yl-ethoxy)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-propionamide;
(434) 2-(R)-hydroxy-N-{4-[7-(2-morpholine-4-yl-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(435) 2-(S)-hydroxy-N-{4-[7-(2-morpholine-4-yl-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(436) {4-[1-methyl-7-(2-morpholine-4-yl-ethoxy)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid isopropylester;
(437) {4-[1-methyl-7-(2-morpholine-4-yl-ethoxy)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid cyclopentylester;
(438) N-{4-[1-methyl-7-(2-morpholine-4-yl-ethoxy)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-2-thiophene-2-yl-acetamide;
(439) 2-chloro-N-{4-[1-methyl-7-(2-morpholine-4-yl-ethoxy)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-benzamide;
(440) [4-(7-ethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(441) N1-(7-ethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine dihydrochloride;
(442) N-[4-(7-ethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(443) [4-(7-ethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isopropylester;
(444) [4-(7-ethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isobutylester;
(445) [4-(7-ethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid cyclopentylester;
(446) N-[4-(7-ethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2-thiophene-2-yl-acetamide;
(447) [4-(7-isopropoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(448) N1-(7-isopropoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine ditrifluoroacetic acid;
(449) N-[-(7-isopropoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(450) N-[4-(7-isopropoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2-methyl-butyramide;
(451) N-[4-(7-isopropoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2-thiophene-2-yl-acetamide;
(452) [4-(7-isopropoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isopropylester;
(453) [4-(7-isopropoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid cyclopentylester;
(454) 2-chloro-N-[4-(7-isopropoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(455) [4-(7-methoxy-1,9-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(456) N1-(7-methoxy-1,9-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine ditrifluoroacetic acid;
(457) [4-(7-methoxy-1,9-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isopropylester;
(458) [4-(7-methoxy-1,9-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(459) [4-(6-chloro-7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(460) [4-(6-chloro-7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine dihydrochloride;
(461) [4-(6-chloro-7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(462) [4-(6-chloro-7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isobutylester;
(463) N-[4-(6-chloro-7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2-thiophene-2-yl-acetamide;
(464) [4-(7-methoxy-1,8-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(465) N1-(7-methoxy-1,8-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine ditrifluoroacetic acid;
(466) N-[4-(7-methoxy-1,8-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2,2-dimethyl-propionamide;
(467) [4-(7-methoxy-1,8-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isopropylester;
(468) [4-(7-methoxy-1,8-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isobutylester;
(469) N-[4-(7-methoxy-1,8-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(470) 2-chloro-N-[4-(7-methoxy-1,8-dimethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl∘|-□|)-butyl]-benzamide;
(471) [4-(7-methoxy-1-methyl-8-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(472) N1-(7-methoxy-1-methyl-8-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine ditrifluoroacetic acid;
(473) [4-(7-methoxy-1-methyl-8-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isopropylester;
(474) [4-(7-methoxy-1-methyl-8-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isobutylester;
(475) [4-(7-methoxy-1-methyl-8-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid cyclopentylester;
(476) N-[4-(7-methoxy-1-methyl-8-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(477) N-[4-(7-methoxy-1-methyl-8-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2,2-dimethyl-propionamide;
(478) 2-(R)-hydroxy-N-[4-(7-methoxy-1-methyl-8-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(479) 2-(S)-hydroxy-N-[4-(7-methoxy-1-methyl-8-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(480) N-[4-(7-methoxy-1-methyl-8-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2-thiophene-2-yl-acetamide;
(481) 2-chloro-N-[4-(7-methoxy-1-methyl-8-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(482) 1-cyclohexyl-3-[4-(7-methoxy-1-methyl-8-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-urea;
(483) {4-[7-methoxy-8-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid-tert-butylester;
(484) N1-[7-methoxy-8-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl]-butane-1,4-diamine ditrifluoroacetic acid;
(485) N-{4-[7-methoxy-8-(2-methoxy-ethoxy)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(486) [4-(7,8,9-trimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(487) N1-(7,8,9-trimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine ditrifluoroacetic acid;
(488) 3-methyl-N-[4-(7,8,9-trimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-butyramide;
(489) 3-methyl-pentanoic acid-[4-(6,8,9-trimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-amide;
(490) [4-(7-imidazole-1-yl-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(491) N1-(7-imidazole-1-yl-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine dihydrochloride;
(492) N-[4-(7-imidazole-1-yl-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(493) [4-(7-imidazole-1-yl-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isobutylester;
(494) [4-(7-imidazole-1-yl-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isopropylester;
(495) 3-methyl-pentanoic acid-[4-(7-imidazole-1-yl-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-amide;
(496) N-[4-(7-imidazole-1-yl-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2-thiophene-2-yl-acetamide;
(497) [4-(1-methyl-7-morpholine-4-yl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(498) N1-(1-methyl-7-morpholine-4-yl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine dihydrochloride;
(499) 3-methyl-N-[4-(1-methyl-7-morpholine-4-yl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-butyramide;
(500) 2-(S)-fluoro-3-methyl-N-[4-(1-methyl-7-morpholine-4-yl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-butyramide;
(501) 3-methyl-pentanoic acid-[4-(1-methyl-7-morpholine-4-yl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-amide;
(502) (S)-{2-methyl-1-[4-(1-methyl-7-morpholine-4-yl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butylcarbamoyl]-propyl}-carbamic acid-tert-butylester;
(503) 2-(S)-amino-3-methyl-N-[4-(1-methyl-7-morpholine-4-yl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-butyramide hydrochloride;
(504) (S)-2-(2-(S)-hydroxy-propionylamino)-3-methyl-N-[4-(1-methyl-7-morpholine-4-yl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-butyramide hydrochloride;
(505) 2-(S)-methanesulfonylamino-3-methyl-N-[4-(1-methyl-7-morphonyl-4-yl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-butyramide;
(506) [4-(1-methyl-7-morpholine-4-yl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isopropylester;
(507) N-[4-(1-methyl-7-morpholine-4-yl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2-thiophene-2-yl-acetamide;
(508) {4-[7-(2,6-dimethyl-morphonyl-4-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid-tert-butylester;
(509) N1-[7-(2,6-dimethyl-morphonyl-4-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl]-butane-1,4-diamine ditrifluoroacetic acid;
(510) N-{4-[7-(2,6-dimethyl-morpholine-4-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(511) N-{4-[7-(2,6-dimethyl-morphonyl-4-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-2-(S)-fluoro-3-methyl-butyramide;
(512) N-{4-[7-(2,6-dimethyl-morpholine-4-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-2-(R)-hydroxy-3-methyl-butyramide;
(513) (S)-(2-methyl-1-{4-[1-methyl-7-(2,6-dimethyl-morpholine-4-yl)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butylcarbamoyl}-propyl)-carbamic acid-tert-butylester;
(514) 2-(S)-amino-N-{4-[7-(2,6-dimethyl-morpholine-4-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide hydrochloride;
(515) (S)-(1-{4-[7-(2,6-dimethyl-morpholine-4-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butylcarbamoyl}-2-methyl-propyl)-carbamic acid isobutylester;
(516) (S)-(1-{4-[7-(2,6-dimethyl-morpholine-4-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butylcarbamoyl}-2-methyl-propyl)-carbamic acid propylester;
(517) (S)—N-(1-{4-[7-(2,6-dimethyl-morpholine-4-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butylcarbamoyl}-2-methyl-propyl)-2-(S)-fluoro-3-methyl-butyramide;
(518) (S)—N-{4-[7-(2,6-dimethyl-morpholine-4-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-2-(3-methyl-butyrylamino)-butyramide;
(519) (S)—N-{4-[7-(2,6-dimethyl-morpholine-4-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-2-(2,2-dimethyl-propionylamino)-3-methyl-butyramide;
(520) (S)-(1-{4-[7-(2,6-dimethyl-morpholine-4-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butylcarbamoyl}-2-methyl-propyl)-carbamic acid isopropylester;
(521) {[4-(1-methyl-7-thiomorpholine-4-yl)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid-tert-butylester;
(522) N-(1-methyl-7-thiomorphonyl-4-yl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine ditrifluoroacetic acid;
(523) 3-methyl-N-[4-(1-methyl-7-thiomorpholine-4-yl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-butyramide;
(524) N-[4-(7-thiomorphonyl-4-yl-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2-(R)-hydroxy-3-methyl-butyramide;
(525) N-[4-(7-thiomorphonyl-4-yl-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2-(S)-hydroxy-3-methyl-butyramide;
(526) {4-[7-(6,7-dihydro-4H-thiano[3,2-c]pyridine-5-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid-tert-butylester;
(527) N1-[7-(6,7-dihydro-4H-thiano[3,2-c]pyridine-5-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl]-butane-1,4-diamine ditrifluoroacetic acid;
(528) N-{4-[7-(6,7-dihydro-4H-thiano[3,2-c]pyridine-5-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(529) N-{4-[7-(6,7-dihydro-4H-thiano[3,2-c]pyridine-5-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-2-(S)-fluoro-3-methyl-butyramide;
(530) 4-(4-tert-butoxycarbonylamino-butylamino)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxylic acid methylester;
(531) 4-(4-tert-butoxycarbonylamino-butylamino)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxylic acid;
(532) [4-(8-isopropylcarbamoyl-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(533) [4-(8-carbamoyl-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(534) 4-(4-isobutyramido-butylamino)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxylic acid isopropylamide;
(535) 4-(4-benzylamino-butylamino)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxylic acid isopropylamide;
(536) {4-[8-(2-dimethylamino-ethylcarbamoyl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid-tert-butylester;
(537) 4-(4-benzoylamino)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxylic acid-(2-dimethylamino-ethyl)-amide;
(538) [4-(1-methyl-8-phenylcarbamoyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(539) N-{4-[8-(4-benzyl-piperazine-1-carbonyl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-benzamide;
(540) N-{4-[1-methyl-8-(piperazine-1-carbonyl)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-benzamide;
(541) [4-(1-methyl-8-nitro-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(542) [4-(8-amino-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(543) [4-(8-isobutyramido-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(544) N-[4-(4-aminobutylamino)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-8-yl]-isobutyramide ditrifluoroacetic acid;
(545) N-[4-(8-isobutyramido-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2,2-dimethyl-propionamide;
(546) [4-(8-acetamino-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(547) N-[4-(8-acetamino-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-2,2-dimethyl-propionamide;
(548) N-[4-(8-acetamino-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(549) N-[4-(8-isobutyramido-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-benzamide;
(550) 3-methyl-N-[4-(1-methyl-8-nitro-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-butyramide;
(551) N-[4-(8-amino-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(552) 3-methyl-N-[4-(1-methyl-8-propylamino-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-butyramide;
(553) N-{4-[8-(3-cyano-propylamino)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(554) N-{4-[8-(3-ethyl-thioureido)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(555) N-[4-(7-methoxy-1-methyl-8-nitro-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(556) N-[4-(8-amino-7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(557) N-[4-(7-methoxy-1-methyl-8-methylamino-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(558) N-[4-(8-hydroxyamino-7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(559) N-[4-(7-methoxy-1-methyl-8-propylamino-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(560) N-[4-(7-methoxy-1-methyl-8-prop-2-ylamino-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(561) N-{4-[8-(3-isopropyl-ureido)-7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(562) N-{4-[7-methoxy-1-methyl-8-(3-methyl-butyrylamino)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(563) N-{7-methoxy-1-methyl-4-[4-(3-methyl-butyrylamino)-[1,2,4]triazolo[4,3-a]quinoxaline-8-ylamino]-butyl}-3,3-dimethyl-butyramide;
(564) N-{4-[7-methoxy-1-methyl-8-(3-phenyl-ureido)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(565) N-[4-(8-methanesulfonylamino-7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(566) N-[4-(8-dimethanesulfonylamino-7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(567) N-{4-[7-methoxy-1-methyl-8-(2-methyl-propane-1-sulfonylamino)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(568) N-{4-[7-methoxy-1-methyl-8-(3-phenyl-ureido)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(569) N-{4-[8-(3-isopropyl-thioureido)-7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(570) {4-[8-(4-methoxy-benzoyl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid-tert-butylester;
(571) [4-(8-benzoyl-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(572) [4-(8-fluoro-7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(573) [4-(7-fluoro-8-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(574) N-[4-(8-fluoro-7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(575) N-[4-(7-fluoro-8-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(576) N-{4-[7-methoxy-1-methyl-8-(2-morpholine-4-yl-ethoxy)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(577) N-{4-[8-methoxy-1-methyl-7-(2-morpholine-4-yl-ethoxy)-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(578) {4-[8-(3,5-dimethyl-isoxazol-4-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid-tert-butylester;
(579) N1-[8-(3,5-dimethyl-isoxazol-4-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl]-butane-1,4-diamine ditrifluoroacetic acid;
(580) N-{4-[8-(3,5-dimethyl-isoxazol-4-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(581) N-{4-[8-(3,5-dimethyl-isoxazol-4-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-2-(R)-hydroxy-3-methyl-butyramide;
(582) N-{4-[8-(3,5-dimethyl-isoxazol-4-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-2-(S)-hydroxy-3-methyl-butyramide;
(583) {4-[7-(3,5-dimethyl-isoxazol-4-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-carbamic acid-tert-butylester;
(584) N1-[7-(3,5-dimethyl-isoxazol-4-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl]-butane-1,4-diamine ditrifluoroacetic acid;
(585) N-{4-[7-(3,5-dimethyl-isoxazol-4-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-3-methyl-butyramide;
(586) N-{4-[7-(3,5-dimethyl-isoxazol-4-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-2-(R)-hydroxy-3-methyl-butyramide;
(587) N-{4-[7-(3,5-dimethyl-isoxazol-4-yl)-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino]-butyl}-2-(S)-hydroxy-3-methyl-butyramide;
(588) N1-[7-methoxy-1-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl]-butane-1,4-diamine ditrifluoroacetic acid;
(589) [4-(7-methoxy-1-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isopropylester;
(590) N-[4-(7-methoxy-1-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(591) 3-methyl-pentanoic acid-[4-(7-methoxy-1-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-amide;
(592) N1-(7,8-dimethoxy-1-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine ditrifluoroacetic acid;
(593) N-[4-(7,8-dimethoxy-1-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(594) [4-(1-ethyl-7,8-dimethoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(595) N1-(1-ethyl-7,8-dimethoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine ditrifluoroacetic acid;
(596) [4-(1-ethyl-7,8-dimethoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isopropylester;
(597) N-[4-(1-ethyl-7,8-dimethoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(598) [4-(1-ethyl-7,8-dimethoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isobutylester;
(599) [4-(1-isopropyl-7,8-dimethoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(600) N1-(1-isopropyl-7,8-dimethoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine ditrifluoroacetic acid;
(601) [4-(1-isopropyl-7,8-dimethoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isopropylester;
(602) [4-(1-isopropyl-7,8-dimethoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isobutylester;
(603) N-[4-(1-isopropyl-7,8-dimethoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(604) [4-(1-phenyl-7,8-dimethoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(605) N1-(1-phenyl-7,8-dimethoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine ditrifluoroacetic acid;
(606) [4-(1-phenyl-7,8-dimethoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isopropylester;
(607) [4-(1-phenyl-7,8-dimethoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isobutylester;
(608) N-[4-(1-phenyl-7,8-dimethoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(610) [4-(1-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(611) N-(1-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine;
(612) N-[4-(1-trifluoromethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-acetamide;
(613) [4-(1-ethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(614) N1-(1-ethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine;
(615) [4-(1-isopropyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(616) N1-(1-isopropyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine;
(617) [4-(1-phenyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(618) N1-(1-phenyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine;
(619) N-[4-(1-phenyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-acetamide;
(620) [4-(7-methoxy-1-ethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(621) N1-(7-methoxy-1-ethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine ditrifluoroacetic acid;
(622) [4-(7-methoxy-1-ethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(623) [4-(7-methoxy-1-ethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isopropylester;
(624) [4-(7-methoxy-1-ethyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isobutylester;
(625) [4-(7-methoxy-1-isopropyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid-tert-butylester;
(626) N1-(7-methoxy-1-isopropyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-butane-1,4-diamine ditrifluoroacetic acid;
(627) [4-(1-isopropyl-7-methoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-3-methyl-butyramide;
(628) [4-(1-isopropyl-7-methoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isopropylester;
(629) [4-(1-isopropyl-7-methoxy-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-butyl]-carbamic acid isobutylester;
(641) tert-butyl(2-((1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)amino)pentyl)carbamate;
(642) [5-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-pentyl]-carbamic acid-tert-butylester;
(643) N1-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-yl)-pentane-1,5-diamine ditrifluoroacetic acid;
(644) [5-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-pentyl]-carbamic acid isopropylester;
(645) N-[5-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-pentyl]-2,2-dimethyl-propionamide;
(646) 5-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-pentanoic acid-tert-butylamide;
(647) 5-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-pentanoic acid isopropylamide;
(648) 5-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-pentanoic acid isobutylamide;
(649) 5-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-pentanoic acid-(2-methyl-butyl)-amide;
(650) 5-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-pentanoic acid-(furan-2-yl-methyl)-amide;
(651) 5-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-pentanoic acid benzylamide;
(652) 5-(7,8-dimethoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-pentanoic acid-(1H-pyrrole-2-yl-methyl)-amide;
(653) 5-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-pentanoic acid-tert-butylamide;
(654) 5-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-pentanoic acid isopropylamide;
(655) 5-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-pentanoic acid isobutylamide;
(656) 5-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-pentanoic acid-(2-methyl-butyl)-amide;
(657) 5-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-pentanoic acid-(furan-2-yl-methyl)-amide;
(658) 5-(7-methoxy-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-pentanoic acid-benzamide;
(659) 5-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-pentanoic acid isopropylamide;
(660) 5-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-pentanoic acid isobutylamide;
(661) 6-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-hexanoic acid isopropylamide; and
(662) 6-(1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline-4-ylamino)-hexanoic acid isobutylamide.

### Claim 5

A preparation method of the compound represented by formula 1 comprising the following steps, as shown in reaction formula 1 below:
preparing the compound represented by formula 4 by reacting the compound represented by formula 2 with the compound represented by formula 3 (step 1); and
preparing the compound represented by formula 1 by reacting the compound represented by formula 4 prepared in step 1 above with the compound represented by formula 5 (step 2):
wherein,
R1 is C1-20 straight or branched alkyl nonsubstituted or substituted with one or more halogens, or C6-20 aryl;
R2 is hydrogen, C1-20 straight or branched alkyl, or C1-20 straight or branched alkoxy;
R3 is hydrogen, nitro, halogen, nonsubstituted or substituted C1-20 straight or branched alkyl, nonsubstituted or substituted C1-20 straight or branched alkoxy, 5-10 membered heteroaryl nonsubstituted or substituted with one or more methyl groups containing one or more heteroatoms selected from the group consisting of N, O and S,
which forms 6 membered cycloalkyl containing one or more heteroatoms selected from the group consisting of S and O along with R4,
wherein, the substituted C1-20 straight or branched alkyl and the substituted C1-20 straight or branched alkoxy can be independently substituted with one or more substituents selected from the group consisting of halogen, C1-3 straight or branched alkoxy, 5-10 membered heterocycloalkyl containing one or more heteroatoms selected from the group consisting of N, O and S, and C6-10 aryl nonsubstituted or substituted with one or more nitro groups,
A1 is hydrogen, or C1-20 straight or branched alkyl,
B1 and B2 are independently hydrogen, C1-20 straight or branched alkyl, diC1-3 straight or branched alkylamino C1-3 straight or branched alkyl, or C6-10 aryl, and B1 and B2 are linked to each other to form 5-10 membered heterocycloalkyl nonsubstituted or substituted with one or more benzyl groups containing one or more heteroatoms selected from the group consisting of N, O and S,
C1 is hydrogen, C1-20 straight or branched alkyl, or C1-20 straight or branched alkoxy,
D1 and D2 are independently hydrogen, hydroxy, C1-20 straight or branched alkyl saturated or containing one or more carbon≡carbon unsaturated bonds, C1-20 straight or branched alkyl nonsubstituted or substituted with one or more cyano groups, or C1-20 straight or branched alkylsulfonyl,
E1 is C1-20 straight or branched alkyl, or C6-10 aryl C1-5 straight or branched alkyl,
F1 is C1-20 straight or branched alkyl, or C6-10 aryl,
G1 is C1-20 straight or branched alkyl, or C6-10 aryl;
R4 is hydrogen, hydroxy, halogen, nitro, C1-20 straight or branched alkyl nonsubstituted or substituted with one or more ═S groups, C1-20 straight or branched alkylsulfanyl nonsubstituted or substituted with one or more oxo (═O) groups, C1-20 straight or branched alkylsulfonyl, 5-10 membered heterocycloalkyloxy nonsubstituted or substituted with one or more C1-5 straight or branched alkoxycarbonyl containing one or more heteroatoms selected from the group consisting of N, O and S, nonsubstituted or substituted 5-10 membered heteroaryl containing one or more heteroatoms selected from the group consisting of N, O and S, nonsubstituted or substituted C1-20 straight or branched alkoxy,
wherein, the substituted 5-10 membered heteroaryl can be substituted with one or more substituents selected from the group consisting of C1-3 straight or branched alkyl, C1-3 straight or branched alkoxy and C1-3 straight or branched alkoxy C1-3 straight or branched alkyl,
wherein, the substituted C1-20 straight or branched alkoxy can be substituted with one or more substituents selected from the group consisting of halogen, cyano, C1-3 straight or branched alkoxy, nonsubstituted or substituted 5-10 membered heterocycloalkyl containing one or more heteroatoms selected from the group consisting of N, O and S, and nonsubstituted or substituted C6-10 aryl,
wherein, the substituted 5-10 membered heterocycloalkyl and the substituted C6-10 aryl can be independently substituted with one or more substituents selected from the group consisting of cyano,
C1-5 straight or branched alkoxycarbonyl, and 5-8 membered heteroaryl nonsubstituted or substituted with one or more N groups,
A3 is hydrogen, or C1-20 straight or branched alkyl,
B3 and B4 are independently hydrogen, C1-20 straight or branched alkyl, diC1-3 straight or branched alkylamino C1-3 straight or branched alkyl, nonsubstituted or substituted C6-10 aryl, nonsubstituted or substituted C6-10 aryl C1-3 straight or branched alkyl, and B3 and B4 are linked to each other to form 5-10 membered heterocycloalkyl nonsubstituted or substituted with one or more benzyl groups containing one or more heteroatoms selected from the group consisting of N, O and S,
wherein, the substituted C6-10 aryl can be substituted with one or more substituents selected from the group consisting of amine, halogen, C1-5 straight or branched alkyl and C1-5 straight or branched alkoxy,
C3, C4 and C5 are independently hydrogen, amine, halogen, C1-20 straight or branched alkyl, or C1-20 straight or branched alkoxy,
D3 and D4 are independently hydrogen, hydroxy, C1-20 straight or branched alkyl saturated or containing one or more carbon≡carbon unsaturated bonds, C1-20 straight or branched alkyl nonsubstituted or substituted with one or more cyano groups, or C1-20 straight or branched alkylsulfonyl nonsubstituted or substituted with one or more halogens, and D3 and D4 are linked to each other to form 5-10 membered heteroaryl containing one or more heteroatoms selected from the group consisting of N, O and S, or 5-10 membered heterocycloalkyl fused with 5 membered heteroaryl nonsubstituted or substituted with one or more methyl groups or containing one S group and one or more heteroatoms selected from the group consisting of N, O and S,
E3 is C1-20 straight or branched alkyl, or C6-10 aryl C1-5 straight or branched alkyl,
F3 is C1-20 straight or branched alkyl, or C6-10 aryl,
G3 is C1-20 straight or branched alkyl, or C6-10 aryl,
H3 is C6-10 aryl, 5-10 membered heterocycloalkyl containing one or more heteroatoms selected from the group consisting of N, O and S, or 5-10 membered heteroaryl nonsubstituted or substituted with one or more methyl groups containing one or more heteroatoms selected from the group consisting of N, O and S,
I3 is diC1-3 straight or branched alkylamino;
R5 is hydrogen, halogen, C1-20 straight or branched alkyl nonsubstituted or substituted with one or more halogens, or C1-20 straight or branched alkoxy;
R6 is
B5 and B6 are independently hydrogen, C1-20 straight or branched alkyl, C6-10 aryl C1-3 straight or branched alkyl, or 5-10 membered heteroaryl C1-3 straight or branched alkyl containing one or more heteroatoms selected from the group consisting of N, O and S,
D5 and D6 are independently hydrogen, hydroxy, C1-20 straight or branched alkyl saturated or containing one or more carbon≡carbon unsaturated bonds, C1-20 straight or branched alkyl nonsubstituted or substituted with one or more cyano groups, or C1-20 straight or branched alkylsulfonyl nonsubstituted or substituted with one or more halogens,
E5 is C1-20 straight or branched alkyl saturated or containing one or more carbon≡carbon unsaturated bonds, C1-20 straight or branched alkoxy saturated or containing one or more carbon═carbon unsaturated bonds, C3-10 cycloalkyloxy, C3-10 cycloalkyl C1-3 straight or branched alkyl, C3-10 cycloalkyl, C6-10 aryloxy, C6-10 aryl C1-3 straight or branched alkoxy, C1-20 straight or branched alkylsulfanyl, nonsubstituted or substituted C6-10 aryl, diC1-3 straight or branched alkylamino, 5-10 membered heterocycloalkyl containing one or more heteroatoms selected from the group consisting of N, O and S, or nonsubstituted or substituted 5-10 membered heteroaryl containing one or more N groups,
wherein, the substituted C1-20 straight or branched alkyl can be substituted with one or more substituents selected from the group consisting of hydroxy, halogen, C1-3 straight or branched alkoxy, C1-3 straight or branched alkylcarbonyloxy, C1-3 straight or branched alkoxycarbonyl, hydroxycarbonyl, C6-10 aryl nonsubstituted or substituted with one or more hydroxyl groups, 5-10 membered heteroaryl containing one or more heteroatoms selected from the group consisting of N, O and S, and
T1 and T2 are independently hydrogen, C1-5 straight or branched alkyl, C1-5 straight or branched alkoxycarbonyl, C1-5 straight or branched alkylcarbonyl nonsubstituted or substituted with one or more halogens or hydroxyl groups, and T1 and T2 are linked to each other to form heterocycloalkyl nonsubstituted or substituted with one or more hydroxyl groups or C1-3 straight or branched alkyl groups containing one S group and one or more heteroatoms selected from the group consisting of N, O and S,
wherein, the substituted C6-10 aryl and the substituted 5-10 membered heteroaryl can be independently substituted with one or more substituents selected from the group consisting of halogen, nitro, C1-5 straight or branched alkyl and C1-5 straight or branched alkoxy,
F5 is C1-20 straight or branched alkyl, C3-10 cycloalkyl, or C6-10 aryl nonsubstituted or substituted with one or more halogens, and
G5 is C1-20 straight or branched alkyl;
M is C1-20 straight or branched alkylene; and
X is —NH—.

### Claim 6

A preparation method of the compound represented by formula 1 comprising the following steps, as shown in reaction formula 2 below:
preparing the compound represented by formula 8 by reacting the compound represented by formula 7 with the compound represented by formula 5 (step 1);
preparing the compound represented by formula 9 by reacting the compound represented by formula 8 prepared in step 1 above with hydrazine hydrate (step 2); and
preparing the compound represented by formula 1 by reacting the compound represented by formula 9 prepared in step 2 above with the compound represented by formula 3 (step 3):
wherein,
R1 is C1-20 straight or branched alkyl nonsubstituted or substituted with one or more halogens, or C6-20 aryl;
R2 is hydrogen, C1-20 straight or branched alkyl, or C1-20 straight or branched alkoxy;
R3 is hydrogen, nitro, halogen, nonsubstituted or substituted C1-20 straight or branched alkyl, nonsubstituted or substituted C1-20 straight or branched alkoxy, 5-10 membered heteroaryl nonsubstituted or substituted with one or more methyl groups containing one or more heteroatoms selected from the group consisting of N, O and S,
which forms 6 membered cycloalkyl containing one or more heteroatoms selected from the group consisting of S and O along with R4,
wherein, the substituted C1-20 straight or branched alkyl and the substituted C1-20 straight or branched alkoxy can be independently substituted with one or more substituents selected from the group consisting of halogen, C1-3 straight or branched alkoxy, 5-10 membered heterocycloalkyl containing one or more heteroatoms selected from the group consisting of N, O and S, and C6-10 aryl nonsubstituted or substituted with one or more nitro groups,
A1 is hydrogen, or C1-20 straight or branched alkyl,
B1 and B2 are independently hydrogen, C1-20 straight or branched alkyl, diC1-3 straight or branched alkylamino C1-3 straight or branched alkyl, or C6-10 aryl, and B1 and B2 are linked to each other to form 5-10 membered heterocycloalkyl nonsubstituted or substituted with one or more benzyl groups containing one or more heteroatoms selected from the group consisting of N, O and S,
C1 is hydrogen, C1-20 straight or branched alkyl, or C1-20 straight or branched alkoxy,
D1 and D2 are independently hydrogen, hydroxy, C1-20 straight or branched alkyl saturated or containing one or more carbon≡carbon unsaturated bonds, C1-20 straight or branched alkyl nonsubstituted or substituted with one or more cyano groups, or C1-20 straight or branched alkylsulfonyl,
E1 is C1-20 straight or branched alkyl, or C6-10 aryl C1-5 straight or branched alkyl,
F1 is C1-20 straight or branched alkyl, or C6-10 aryl,
G1 is C1-20 straight or branched alkyl, or C6-10 aryl;
R4 is hydrogen, hydroxy, halogen, nitro, C1-20 straight or branched alkyl nonsubstituted or substituted with one or more ═S groups, C1-20 straight or branched alkylsulfanyl nonsubstituted or substituted with one or more oxo (═O) groups, C1-20 straight or branched alkylsulfonyl, 5-10 membered heterocycloalkyloxy nonsubstituted or substituted with one or more C1-5 straight or branched alkoxycarbonyl containing one or more heteroatoms selected from the group consisting of N, O and S, nonsubstituted or substituted 5-10 membered heteroaryl containing one or more heteroatoms selected from the group consisting of N, O and S, nonsubstituted or substituted C1-20 straight or branched alkoxy,
wherein, the substituted 5-10 membered heteroaryl can be substituted with one or more substituents selected from the group consisting of C1-3 straight or branched alkyl, C1-3 straight or branched alkoxy and C1-3 straight or branched alkoxy C1-3 straight or branched alkyl,
wherein, the substituted C1-20 straight or branched alkoxy can be substituted with one or more substituents selected from the group consisting of halogen, cyano, C1-3 straight or branched alkoxy, nonsubstituted or substituted 5-10 membered heterocycloalkyl containing one or more heteroatoms selected from the group consisting of N, O and S, and nonsubstituted or substituted C6-10 aryl,
wherein, the substituted 5-10 membered heterocycloalkyl and the substituted C6-10 aryl can be independently substituted with one or more substituents selected from the group consisting of cyano,
C1-5 straight or branched alkoxycarbonyl, and 5-8 membered heteroaryl nonsubstituted or substituted with one or more N groups,
A3 is hydrogen, or C1-20 straight or branched alkyl,
B3 and B4 are independently hydrogen, C1-20 straight or branched alkyl, diC1-3 straight or branched alkylamino C1-3 straight or branched alkyl, nonsubstituted or substituted C6-10 aryl, nonsubstituted or substituted C6-10 aryl C1-3 straight or branched alkyl, and B3 and B4 are linked to each other to form 5-10 membered heterocycloalkyl nonsubstituted or substituted with one or more benzyl groups containing one or more heteroatoms selected from the group consisting of N, O and S,
wherein, the substituted C6-10 aryl can be substituted with one or more substituents selected from the group consisting of amine, halogen, C1-5 straight or branched alkyl and C1-5 straight or branched alkoxy,
C3, C4 and C5 are independently hydrogen, amine, halogen, C1-20 straight or branched alkyl, or C1-20 straight or branched alkoxy,
D3 and D4 are independently hydrogen, hydroxy, C1-20 straight or branched alkyl saturated or containing one or more carbon≡carbon unsaturated bonds, C1-20 straight or branched alkyl nonsubstituted or substituted with one or more cyano groups, or C1-20 straight or branched alkylsulfonyl nonsubstituted or substituted with one or more halogens, and D3 and D4 are linked to each other to form 5-10 membered heteroaryl containing one or more heteroatoms selected from the group consisting of N, O and S, or 5-10 membered heterocycloalkyl fused with 5 membered heteroaryl nonsubstituted or substituted with one or more methyl groups or containing one S group and one or more heteroatoms selected from the group consisting of N, O and S,
E3 is C1-20 straight or branched alkyl, or C6-10 aryl C1-5 straight or branched alkyl,
F3 is C1-20 straight or branched alkyl, or C6-10 aryl,
G3 is C1-20 straight or branched alkyl, or C6-10 aryl,
H3 is C6-10 aryl, 5-10 membered heterocycloalkyl containing one or more heteroatoms selected from the group consisting of N, O and S, or 5-10 membered heteroaryl nonsubstituted or substituted with one or more methyl groups containing one or more heteroatoms selected from the group consisting of N, O and S,
I3 is diC1-3 straight or branched alkylamino;
R5 is hydrogen, halogen, C1-20 straight or branched alkyl nonsubstituted or substituted with one or more halogens, or C1-20 straight or branched alkoxy;
R6 is
B5 and B6 are independently hydrogen, C1-20 straight or branched alkyl, C6-10 aryl C1-3 straight or branched alkyl, or 5-10 membered heteroaryl C1-3 straight or branched alkyl containing one or more heteroatoms selected from the group consisting of N, O and S,
D5 and D6 are independently hydrogen, hydroxy, C1-20 straight or branched alkyl saturated or containing one or more carbon≡carbon unsaturated bonds, C1-20 straight or branched alkyl nonsubstituted or substituted with one or more cyano groups, or C1-20 straight or branched alkylsulfonyl nonsubstituted or substituted with one or more halogens,
E5 is C1-20 straight or branched alkyl saturated or containing one or more carbon≡carbon unsaturated bonds, C1-20 straight or branched alkoxy saturated or containing one or more carbon═carbon unsaturated bonds, C3-10 cycloalkyloxy, C3-10 cycloalkyl C1-3 straight or branched alkyl, C3-10 cycloalkyl, C6-10 aryloxy, C6-10 aryl C1-3 straight or branched alkoxy, C1-20 straight or branched alkylsulfanyl, nonsubstituted or substituted C6-10 aryl, diC1-3 straight or branched alkylamino, 5-10 membered heterocycloalkyl containing one or more heteroatoms selected from the group consisting of N, O and S, or nonsubstituted or substituted 5-10 membered heteroaryl containing one or more N groups,
wherein, the substituted C1-20 straight or branched alkyl can be substituted with one or more substituents selected from the group consisting of hydroxy, halogen, C1-3 straight or branched alkoxy, C1-3 straight or branched alkylcarbonyloxy, C1-3 straight or branched alkoxycarbonyl, hydroxycarbonyl, C6-10 aryl nonsubstituted or substituted with one or more hydroxyl groups, 5-10 membered heteroaryl containing one or more heteroatoms selected from the group consisting of N, O and S, and
T1 and T2 are independently hydrogen, C1-5 straight or branched alkyl, C1-5 straight or branched alkoxycarbonyl, C1-5 straight or branched alkylcarbonyl nonsubstituted or substituted with one or more halogens or hydroxyl groups, and T1 and T2 are linked to each other to form heterocycloalkyl nonsubstituted or substituted with one or more hydroxyl groups or C1-3 straight or branched alkyl groups containing one S group and one or more heteroatoms selected from the group consisting of N, O and S,
wherein, the substituted C6-10 aryl and the substituted 5-10 membered heteroaryl can be independently substituted with one or more substituents selected from the group consisting of halogen, nitro, C1-5 straight or branched alkyl and C1-5 straight or branched alkoxy,
F5 is C1-20 straight or branched alkyl, C3-10 cycloalkyl, or C6-10 aryl nonsubstituted or substituted with one or more halogens,
G5 is C1-20 straight or branched alkyl;
M is C1-20 straight or branched alkylene; and
X is —NH—.