# US 11,028,078 B2 · Itraconazole analogs and use thereof

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 11,028,078 B2
- Document ID: US11028078B2
- Status: Granted
- Kind: B2
- Application number: 16/152,008
- Filed: 2018-10-04
- Published: 2019-02-07
- Granted: 2021-06-08
- Earliest claimed: 2011-09-07
- Assignees: The Johns Hopkins University
- Applicants: The Johns Hopkins University
- Inventors: Jun O. Liu; Yingjun Li; Kalyan Kumar Pasunooti; Wukun Liu; Wei Shi; Ruojing Li; Sarah Head
- Web page: https://patentgrep.com/patent/US11028078B2

## CPC

- C07D 405/14: containing three or more hetero rings
- A61K 31/496: Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A61K 31/506: not condensed and containing further heterocyclic rings
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Provided herein are Itraconazole analogs. Also provided herein are methods of inhibition of Hedgehog pathway, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, angiogenesis and treatment of disease with Itraconazole analogs.

## Claims

### Claim 1

A compound selected from:
Compund
Structure
Number
214
215
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298

### Claim 2 (depends on 1)

A pharmaceutical composition comprising an effective amount of a compound according to claim 1, and a pharmaceutically acceptable carrier.