# US 11,028,075 B2 · Therapeutic compounds and methods of use thereof

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- Number: US 11,028,075 B2
- Document ID: US11028075B2
- Status: Granted
- Kind: B2
- Application number: 16/283,451
- Filed: 2019-02-22
- Published: 2019-08-29
- Granted: 2021-06-08
- Earliest claimed: 2018-02-26
- Assignees: Genentech, Inc.
- Applicants: Genentech, Inc.
- Inventors: Daniel Sutherlin; Steven McKerrall; Kwong Wah Lai; Zhiguo Liu; Wenfeng Liu; Ramsay Beveridge; Jean-Philippe Leclerc; Alexandre Lemire; Liang Zhao; Claudio Sturino
- Web page: https://patentgrep.com/patent/US11028075B2

## CPC

- C07D 403/12: linked by a chain containing hetero atoms as chain links
- A61K 31/505: Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K 31/506: not condensed and containing further heterocyclic rings
- A61K 31/538: ortho- or peri-condensed with carbocyclic ring systems
- A61K 31/63: Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 17/04: Antipruritics
- C07B 59/002: {Heterocyclic compounds}
- C07D 233/96: having three double bonds between ring members or between ring members and non-ring members
- C07D 239/69: Benzenesulfonamido-pyrimidines
- C07D 263/52: condensed with carbocyclic rings or ring systems
- C07D 305/06: with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring atoms
- C07D 401/12: linked by a chain containing hetero atoms as chain links
- C07D 401/14: containing three or more hetero rings
- C07D 413/12: linked by a chain containing hetero atoms as chain links
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07B: GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR (preparation of carboxylic acid esters by telomerisation C07C67/47; telomerisation C08F)

## Abstract

The invention provides benzene sulfonamides and pharmaceutically acceptable salt thereof that are useful as sodium channel blockers for the treatment of, for example, pain. The following compound is illustrative:

## Claims

### Claim 1

A compound selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.

### Claim 2 (depends on 1)

A pharmaceutical composition comprising a compound of claim 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

### Claim 3 (depends on 1)

The compound of claim 1, which is:
or a pharmaceutically acceptable salt thereof.

### Claim 4 (depends on 1)

The compound of claim 1, which is:
or a pharmaceutically acceptable salt thereof.

### Claim 5 (depends on 1)

The compound of claim 1, which is:
or a pharmaceutically acceptable salt thereof.

### Claim 6 (depends on 1)

The compound of claim 1, which is:
or a pharmaceutically acceptable salt thereof.

### Claim 7 (depends on 1)

The compound of claim 1, which is:
or a pharmaceutically acceptable salt thereof.

### Claim 8 (depends on 1)

The compound of claim 1, which is:
or a pharmaceutically acceptable salt thereof.

### Claim 9 (depends on 1)

The compound of claim 1, which is:
or a pharmaceutically acceptable salt thereof.

### Claim 10 (depends on 1)

The compound of claim 1, which is:
or a pharmaceutically acceptable salt thereof.